布地奈德鼻喷雾剂与鼻内镜手术联合治疗鼻息肉患者的效果分析

Effect Analysis of Budesonide Nasol Spray Combined with Nasal Endoscopic Surgery in the Treatment of Patients with Nasal Polyps

目的:研究布地奈德鼻喷雾剂与鼻内镜手术联合治疗鼻息肉患者的效果。方法:回顾性选取2020年2月—2023年2月日照市岚山区人民医院收治的100例鼻息肉患者资料为研究对象,依据治疗方法的不同,分为联合治疗组与单独治疗组,各50例。单独治疗组采用鼻内镜手术治疗,联合治疗组在单独治疗组基础上联合应用布地奈德鼻喷雾剂。比较两组疼痛情况、鼻腔鼻窦功能、鼻内镜影像改善效果、生活质量、实验室炎症指标、治疗效果、术后并发症发生情况及复发情况。结果:联合治疗组治疗优良率为96.00%,高于单独治疗组的84.00%,复发率为6.00%,低于单独治疗组的20.00%,并发症发生率为6.00%,低于单独治疗组的28.00%,差异均有统计学意义(P<0.05)。治疗后,联合治疗组鼻黏膜嗜酸性粒细胞计数、嗜酸性粒细胞阳离子蛋白、超敏C反应蛋白、总免疫球蛋白、白细胞介素(IL)-4、IL-5及IL-17均低于单独治疗组,基质金属蛋白酶-9高于单独治疗组,差异均有统计学意义(P<0.05)。治疗后,联合治疗组鼻腔鼻窦结局测试-20量表、Lund-Kennedy评分系统、疼痛视觉模拟评分均低于单独治疗组,生活质量综合评定问卷-74评分高于单独治疗组,差异均有统计学意义(P<0.05)。结论:布地奈德鼻喷雾剂联合鼻内镜手术应用于鼻息肉患者的治疗中效果尚佳,能够改善鼻内镜影像效果,减轻疼痛程度,抑制炎症指标,提高患者生活质量,降低并发症发生率和复发率。

Objective:To study the effect analysis of Budesonide Nasol Spray combined with nasal endoscopic surgery in the treatment of patients with nasal polyps.Methods:Data of 100 patients with nasal polyps treated in Lanshan District People’s Hospital of Rizhao City from February 2020 to February 2023 were retrospectively selected as the study objects.According to different treatment methods,they were divided into a combined treatment group and a single treatment group,with 50 cases each group.The single treatment group was treated with nasal endoscopic surgery,and the combined treatment group was treated with Budesonide Nasol Spray on the basis of the single treatment group.The pain condition,nasal and sinus function,nasal endoscopic imaging improvement,quality of life,laboratory inflammatory indexes,therapeutic effect,the occurrence of postoperation complications and recurrence were compared between the two groups.Results:The treatment excellent and good rate of the combined treatment group was 96.00%,which was higher than 84.00%of the single treatment group,the recurrence rate was 6.00%,which was lower than 20.00%of the single treatment group,the complication rate was 6.00%,which was lower than 28.00%of the single treatment group,with statistical significances(P<0.05).After treatment,the nasal eosinophil count,eosinophil cationic protein,hypersensitive C-reactive protein,total immunoglobulin,interleukin(IL)-4,IL-5 and IL-17 in the combined treatment group were lower than those in the single treatment group,and the matrix metalloproteinase-9 was higher than that in the single treatment group,with statistical significances(P<0.05).After treatment,the scores in the Sinus and Nasal Outcome Test-20 scale,Lund-Kennedy score system and pain Visual Analogu Scale of the combined treatment group were lower than those of the single treatment group,the score of Generic Quality of Life Inventory-74 was higher than that of the single treatment group,with statistical significances(P<0.05).Conclusion:Budesonide Nasol Spray combined with nasal endoscopic surgery has a good effect in the treatment of patients with nasal polyps,which can improve perioperative indicators and nasal endoscopic imaging effects,reduce pain,inhibit inflammation indicators,improve patients’quality of life,and reduce the incidence of complications and recurrence.