髓内钉内固定术治疗四肢骨干创伤骨折患者的效果分析

Effect Analysis of Intramedullary Nailing Internal Fixation Surgery in Traumatic Frature of Limbs

目的:探讨髓内钉内固定术治疗四肢骨干创伤骨折患者的效果分析。方法:选取2021年6月—2024年3月单县中心医院收治的120例四肢骨干创伤骨折患者作为研究对象,采用随机数表法将其分为对照组和研究组,每组60例。对照组接受钢板螺钉内固定术治疗,研究组接受髓内钉内固定术治疗。对比两组的围手术期指标、氧化应激指标水平、炎症因子和骨代谢水平及并发症发生情况。结果:与对照组比较,研究组术中出血量较少,手术时间、术后首次下床时间、住院时间和骨折愈合时间均较短,差异均有统计学意义(P<0.05)。术后,研究组超氧化物歧化酶、谷胱甘肽过氧化物酶均高于对照组,丙二醛低于对照组,差异均有统计学意义(P<0.05)。术后1 d,研究组超敏C反应蛋白及白细胞介素-6均低于对照组,差异均有统计学意义(P<0.05)。术后1个月,研究组Ⅰ型原胶原羟基端延长肽、骨γ-羟基谷氨酸蛋白均高于对照组,差异均有统计学意义(P<0.05)。研究组并发症发生率5.00%低于对照组的16.67%,差异有统计学意义(P<0.05)。结论:髓内钉内固定术治疗四肢骨干创伤骨折,有助于减少术中出血量,缩短手术时间、术后下床时间、住院时间和骨折愈合时间,改善氧化应激、炎症因子和骨代谢水平,降低并发症发生率。

Objective:To investigate the effect of intramedullary nailing interral fixation surgery in treatment of patients with traumatic fracture of limbs.Methods:A total of 120 patients with traumatic fracture of limbs were selected from June 2021 to March 2024 in Shanxian central hospital as research objects,and were divided into a control group and a study group by random number table method,with 60 cases in each group.The control group received internal fixation sugery and the study group received intramedullary nailing internal fixation surgery.The perioperative indexes,oxidative stress indexes levels,inflammatory factors and bone metabolism levels and occurrere of complications were compared between the two groups.Results:Compared with the control group,the study group had less intraoperative blood loss,shorter operation time,first time of getting out of bed after surgery,hospital stay and fracture healing time.Three days after surgery,superoxide dismutase and glutathione peroxidase in the study group were higher than those in the control group,and malondialdehyde was lower than that in the control group,with statistical significance(P<0.05).On the first day after surgery,hypersensitive C-reactive protein and interleukin-6 in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).At 1 month after surgery,typeⅠprocollagen hydroxy-end elongating peptide and bone gamma-hydroxyglutamate protein in the study group were higher than those in the control group,with statistical significances(P<0.05).The incidence of complications 5.00%in the study group was lower than 16.67%in the control group,with statistical significance(P<0.05).Conclusion:Intramedullary nailing fixation surgery is helpful to reduce intraoperative blood loss,shorten operative time,postoperative time of getting out of bed,hospital stay and fracture healing time,improve the levels of oxidative stress,inflammatory factors and bone metabolism,and reduce the incidence of complications.