夏枯草口服液联合左甲状腺素钠片治疗桥本甲状腺炎伴甲减患者的有效性及安全性研究

Efficacy and Safety of the Combination of Xiakucao Oral Liquid and Levothyroxine Sodium Tablets in the Treatment of Patiens with Hashimoto Thyroiditis with Hypothyroidism

目的:探究夏枯草口服液与左甲状腺素钠片联合治疗桥本甲状腺炎(HT)伴甲减的有效性及安全性。方法:选取2021年1月—2023年12月兰陵县人民医院收治的84例HT伴甲减患者为研究对象,按照随机数字表法将其分为对照组和研究组,各42例。其中对照组采用左甲状腺素钠片治疗,研究组在对照组基础上采用夏枯草口服液治疗。比较两组临床疗效、中医症候积分、甲状腺功能及不良反应。结果:治疗后,研究组治疗总有效率92.86%高于对照组的76.19%;研究组颈前肿大、颈部发胀、胸闷不适及乏力的中医症候积分均低于对照组;研究组血清游离三碘甲状腺原氨酸及血清游离甲状腺素均高于对照组,促甲状腺素水平低于对照组,差异均有统计学意义(P<0.05)。研究组不良反应发生率7.14%与对照组不良反应发生率11.90%比较,差异无统计学意义(P>0.05)。结论:夏枯草口服液联合左甲状腺素钠片治疗HT伴甲减患者效果显著,可有效改善患者症状及甲状腺功能,且较为安全。

Objective:To investigate the efficacy and safety of the combination of Xiakucao Oral Liquid and Levothyroxine Sodium Tablets in the treatment of hashimoto thyroiditis(HT)with hypothyroidism.Methods:A total of 84 patients with hypothyroidism admitted to Lanling County People’s Hospital from January 2021 to December 2023 were selected and divided into a control group and a study group according to random number table method,with 42 cases in each group.The control group was treated with Levothyroxine Sodium Tablets,and the study group was treated with Prunella Oral Liquid on the basis of the control group.The clinical efficacy,TCM symptom score,thyroid function and adverse reactions were compared between the two groups.Results:After treatment,the total effective rate of the study group was 92.86%higher than 76.19%of the control group;the scores of traditional Chinese medicine symptoms of anterior neck swelling,neck distension,chest discomfort and fatigue in the study group were lower than those in the control group;the serum free triiodothyronine level and serum free thyroxine level of the study group were higher than those of the control group,and the thyrotropin level was lower than that of the control group,with statistical significances(P<0.05).The incidence of adverse reactions in the study group was 7.14%,which was not statistically significant compared with 11.90%in the control group(P<0.05).Conclusion:The effect of the combination of Xiakucao Oral Liquid and Levothyroxine Sodium Tablets in the treatment of hashimoto thyroiditis with hypothyroidism is significant,which can effectively improve the symptoms and thyroid function of patients,and is relatively safe.