KCNE单核苷酸多态性与心血管疾病及内耳疾病的相关性研究

Correlation between KCNE single nucleotide polymorphisms and cardiovascular diseases

KCNE辅助亚基参与调控多种电压门控钾离子通道,对维持机体正常的生理功能十分重要。目前许多研究显示,KCNE家族的单核苷酸多态性(SNP)与心血管疾病和内耳疾病的发生密切相关,但由于其复杂的遗传机制及其易受到地域、种族和个体差异等的影响,还需对KCNE SNP与疾病易感性之间的相关性及遗传规律进行探索,以探讨KCNE SNP作为诊断某些疾病的潜在生物标志物的可能。故该文主要就KCNE SNP与心血管疾病和内耳疾病之间相关性的研究进展进行综述,旨在为疾病的预防及治疗提供理论依据。

KCNE auxiliary subunits are involved in the regulation of various voltage-gated potassium channels,which are important for maintaining normal physiological functions of the body.Current studies have shown that single nucleotide polymorphisms(SNP)in the KCNE family are closely related to the occurrence of cardiovascular and inner ear diseases,and due to its complex genetic mechanism and its susceptibility to geographical,racial and individual differences,it is necessary to explore the correlation of KCNE SNPs and susceptibility to diseases with the genetic pattern,in order to explore the possibility that the KCNE SNPs may serve as a potential biomarker for the diagnosis of certain diseases.KCNE SNPs may be potential biomarkers for diagnosing some diseases.This article summarizes the research progress on the correlation of KCNE SNP with cardiovascular diseases and inner ear diseases,aiming to provide a theoretical basis for disease prevention and treatment.