下肢动脉硬化闭塞症支架置入术后支架内再狭窄的危险因素分析

Analysis of Risk Factors for In-stent Restenosis after Placement of Stent in Lower Extremity Atherosclerotic Obliterans

目的探究下肢动脉硬化闭塞症支架置入术后支架内再狭窄的危险因素。方法选取62例下肢动脉硬化闭塞症支架置入术后支架内再狭窄患者(再狭窄组)为研究对象,另选取本院下肢动脉硬化闭塞症支架置入术后未发生狭窄患者62例(未狭窄组)进行病例对照研究,分析再狭窄组与未再狭窄组相关资料,通过二元logistic回归分析下肢动脉硬化闭塞症支架置入术后支架内再狭窄影响因素。结果单因素分析结果显示,2组在年龄、身体质量指数(BMI)、性别、Fontaine分类、高血压、冠心病、高脂血症、病程、血管病变长度、病变侧别、置入支架数量、低密度脂蛋白、高密度脂蛋白、甘油三酯、血小板、单核细胞计数、淋巴细胞计数、中性粒细胞计数、肾小球滤过率比较,差异无统计学意义(P>0.05),但在长期吸烟、糖尿病、术后规律服药、血小板/淋巴细胞比值(PLR)、中性粒细胞/淋巴细胞比值(NLR)、TIMI评分、HEART评分、ABI值比较,差异有统计学意义(P<0.05)。二元logistic回归分析显示,长期吸烟、糖尿病、术后规律服药、PLR、NLR、TIMI评分、HEART评分、ABI评分均是下肢动脉硬化闭塞症支架置入术后支架内再狭窄影响因素(P<0.05)。结论长期吸烟、糖尿病、术后规律服药、PLR、NLR、TIMI评分、HEART评分、ABI评分均是下肢动脉硬化闭塞症支架置入术后支架内再狭窄影响因素。

Objective To investigate the risk factors for in-stent restenosis after stenting for lower extremity atherosclerotic obliterans.Methods Sixty-two patients with in-stent restenosis after stenting for lower extremity atherosclerotic obliterans(restenosis group)were selected for the study,and 62 patients with no stenosis after stenting for lower extremity atherosclerotic occlusive disease in this hospital(non-restenosis group)were selected as the control group.The data of the restenosis group and the non-restenosis group were analyzed,and the factors affecting in-stent restenosis after stenting for lower limb atherosclerotic occlusive disease were analyzed by binary logistic regression.Results The results of univariate analysis showed that the differences between the 2 groups in age,body mass index(BMI),gender,Fontaine’s classification,hypertension,coronary heart disease,hyperlipidemia,disease duration,length of vascular lesion,side of lesion,number of stents inserted,low-density lipoprotein(LDL),high-density lipoprotein(HDL),triglyceride,platelet,monocyte count,lymphocyte count,neutrophil,and glomerular filtration rate were not statistically significant(P>0.05),but the differences were statistically significant in long-term smoking,diabetes,regular postoperative medication,platelet/lymphocyte ratio(PLR),neutrophil/lymphocyte ratio(NLR),TIMI scores,HEART scores,and ABI values(P<0.05).Binary logistic regression analysis showed that long-term smoking,diabetes mellitus,regular post-procedure medication,PLR,NLR,TIMI score,HEART score,and ABI score were factors influencing in-stent restenosis after stenting for lower extremity atherosclerotic occlusive disease(P<0.05).Conclusion Long-term smoking,diabetes mellitus,regular post-procedure medication,PLR,NLR,TIMI score,HEART score,and ABI score are all factors influencing in-stent restenosis after placement of stent in lower extremity atherosclerotic obliterans.