不同病理类型非小细胞肺癌的VEGF-A和VEGFR-2表达

Expression of VEGF-A and VEGFR-2 in Different Pathological Types of Non-small Cell Lung Cancer

目的探讨不同病理类型非小细胞肺癌(NSCLC)的VEGF-A和VEGFR-2表达。方法选择NSCLC患者72例作为研究对象,其中病理诊断为鳞癌40例(鳞癌组),腺癌32例(腺癌组)。采用qRCR方法检测病灶组织样本VEGF-A和VEGFR-2 mRNA表达水平,分析其与患者病理特征的相关性。结果鳞癌组的VEGF-A和VEGFR-2 mRNA相对表达水平低于腺癌组(P<0.05)。在腺癌组和鳞癌组中,不同分化程度、临床分期、淋巴结转移患者的VEGF-A和VEGFR-2 mRNA相对表达水平对比差异均有统计学意义(P<0.05)。无论是肺腺癌还是鳞癌,其分化程度、临床分期、淋巴结转移与VEGF-A、VEGFR-2 mRNA相对表达水平均存在相关性(P<0.05)。Logistic回归模型分析显示VEGF-A、VEGFR-2均为影响肺癌发生的重要因素(P<0.05)。结论肺腺癌的VEGF-A和VEGFR-2 mRNA表达水平高于肺鳞癌,二者的VEGF-A、VEGFR-2 mRNA均与患者的肿瘤分化程度、临床分期、淋巴结转移存在相关性。VEGF-A、VEGFR-2是导致肺癌发生的重要影响因素。

Objective To investigate the expression differences of VEGF-A and VEGFR-2 in different pathological types of non-small cell lung cancer.Methods 72 NSCLC patients were selected as the research subjects,including 40 cases diagnosed with squamous cell carcinoma(squamous cell carcinoma group)and 32 cases diagnosed with adenocarcinoma(adenocarcinoma group).QRCR method was used to detect the mRNA expression levels of VEGF-A and VEGFR-2 in lesion tissue samples,investigate the pathological characteristics of patients,and conduct correlation analysis.Results Expression levels of VEGF-A and VEGFR-2 mRNA in squamous cell carcinoma was lower than adenocarcinoma group(P<0.05).There was a statistically significant difference in the relative expression levels of VEGF-A and VEGFR-2 mRNA between patients with different differentiation levels,clinical stages,and lymph node metastasis in the adenocarcinoma and squamous cell carcinoma groups(P<0.05).There was a correlation between differentiation degree,clinical stage,lymph node metastasis,and relative expression levels of VEGF-A and VEGFR-2 mRNA in the adenocarcinoma and squamous cell carcinoma groups(P<0.05).Logistic regression analysis showed that VEGF-A and VEGFR-2 were important factors affecting the occurrence of lung cancer(P<0.05).Conclusion The expression levels of VEGF-A and VEGFR-2 mRNA in adenocarcinoma are higher than those in squamous cell carcinoma,and are correlated with the differentiation degree,clinical stage,and lymph node metastasis of patients.They are also important influencing factors leading to the occurrence of lung cancer.