肺癌患者血清NSE、CYFRA21-1、Pro-GRP的表达及其与临床病理特征的关系

Expression of Serum NSE,CYFRA21-1,Pro-GRP in Lung Cancer Patients and Their Relationship with Clinical Pathological Characteristics

目的探讨肺癌患者血清神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、胃泌素释放肽前体(Pro-GRP)的表达及其与临床病理特征的关系。方法选择88例肺癌患者作为恶性组,50例肺部良性疾病患者作为良性组,50例健康体检者作为对照组。采集3组受检者空腹肘正中静脉血5 ml,离心取上清液,检测NSE、CYFRA21-1、Pro-GRP水平。对比3组NSE、CYFRA21-1、Pro-GRP水平,分析NSE、CYFRA21-1、Pro-GRP水平与肺癌患者的临床病理特征的关系。结果恶性组NSE、CYFRA21-1、Pro-GRP水平高于良性组和对照组,且良性组各指标水平较对照组高,差异有统计学意义(P<0.05)。TNM分期Ⅲ~Ⅳ期、低中分化和有淋巴结转移者NSE、CYFRA21-1、Pro-GRP水平高于Ⅰ~Ⅱ期、高分化和无淋巴结转移者,差异有统计学意义(P<0.05);不同病理类型、肿瘤直径肺癌患者NSE、CYFRA21-1、Pro-GRP水平比较,差异无统计学意义(P>0.05)。NSE、CYFRA21-1、Pro-GRP水平与肺癌患者TNM分期、淋巴结转移呈正相关(P<0.05),与分化程度呈负相关(P<0.05)。结论肺癌患者血清NSE、CYFRA21-1、Pro-GRP异常升高,其水平高低与患者TNM分期、分化程度、有无淋巴结转移密切相关。

Objective To investigate the expression of serum neuron specific enolase(NSE),cytokeratin 19 fragment(CYFRA21-1),and gastrin releasing peptide precursor(Pro-GRP)in lung cancer patients and their relationship with clinical and pathological characteristics.Methods 88 lung cancer patients were selected and assigned to the malignant group,50 patients with benign lung diseases were assigned to the benign group,and 50 healthy individuals were assigned to the control group.Collect 5ml of fasting elbow median vein blood from the 3 groups of subjects,centrifuge the supernatant,and detect NSE,CYFRA21-1,and Pro-GRP.Compared the differences in NSE,CYFRA21-1,and Pro-GRP levels among the 3 groups,and analyzed the clinical pathological characteristics of lung cancer patients with NSE,CYFRA21-1,and Pro-GRP levels.Results NSE,CYFRA21-1,and Pro-GRP levels in the malignant group were higher than those in the benign group and control group,and levels of various indicators in the benign group were higher than those in the control group,with statistical differences(P<0.05).NSE,CYFRA21-1,and Pro-GRP levels in patients with TNM stagingⅢ~Ⅳ,low to medium differentiation,and lymph node metastasis were higher than those in patients with stageⅠ~Ⅱ,high differentiation,and no lymph node metastasis,with statistical differences(P<0.05);There was no statistically significant difference in NSE,CYFRA21-1,and Pro-GRP levels among lung cancer patients with different pathological types and tumor diameters(P>0.05).T NSE,CYFRA21-1,and Pro-GRP levels were positively correlated with TNM staging and lymph node metastasis in lung cancer patients(P<0.05),and negatively correlated with the degree of differentiation(P<0.05).Conclusion Serum NSE,CYFRA21-1,and Pro-GRP levels in lung cancer patients are abnormally elevated,and their levels are closely related to TNM staging,differentiation,and lymph node metastasis.