鼻咽癌组织中HDAC1、HDAC7及ZNF191蛋白表达情况及其临床价值

Analysis of the Expression and Clinical Value of HDAC1,HDAC7,and ZNF191 Proteins in Nasopharyngeal Carcinoma Tissue

目的探讨鼻咽癌组织内组蛋白去乙酰化酶1(HDAC1)、HDAC7及锌指转录因子191(ZNF191)蛋白表达与临床病理特征及预后的相关性。方法选取88例鼻咽癌患者,均经鼻内镜采集肿瘤标本及癌旁正常标本并送检,比较肿瘤及正常组织内HDAC1、HDAC7及ZNF191蛋白表达情况,并分析HDAC1、HDAC7及ZNF191蛋白表达与临床病理特征及预后的关系。结果肿瘤组织内HDAC1、HDAC7及ZNF191阳性表达较正常组织高(P<0.05)。HDAC1、HDAC7及ZNF191阳性表达患者的肿瘤分期Ⅲ~Ⅳ期、淋巴结转移占比较阴性患者高(P<0.05)。88例患者随访2年,共出现26例复发转移,发生率为29.55%(26/88);复发转移患者HDAC1、HDAC7及ZNF191阳性率较未复发转移患者高(P<0.05)。结论HDAC1、HDAC7及ZNF191在鼻咽癌组织内呈高表达状态,与肿瘤分期、淋巴结转移关系密切,且可明显增加复发转移风险。

Objective To investigate the correlation between the expression of histone deacetylase 1(HDAC1),HDAC7,and zinc finger transcription factor 191(ZNF191)proteins in nasopharyngeal carcinoma tissue and their clinical pathological characteristics and prognosis.Methods 88 patients with nasopharyngeal carcinoma were selected as the research subjects.All patients underwent nasal endoscopy to collect tumor specimens and normal specimens for examination.The expression of HDAC1,HDAC7,and ZNF191 proteins in tumor and normal tissues was compared,and the relationship between HDAC1,HDAC7,and ZNF191 protein expression and clinical pathological characteristics and prognosis was analyzed.Results The positive expressions of HDAC1,HDAC7,and ZNF191 in tumor tissue were higher than those in normal tissue,with statistical significance(P<0.05);The proportion of tumor stageⅢ~Ⅳand lymph node metastasis in patients with positive expression of HDAC1,HDAC7,and ZNF191 was higher than that in negative patients,and the difference was statistically significant(P<0.05);88 patients were followed up for 2 years,with a total of 26 cases experiencing recurrence and metastasis,with an incidence rate of 29.55%(26/88);The positive rates of HDAC1,HDAC7,and ZNF191 in patients with recurrence and metastasis were higher than those in patients without recurrence and metastasis,and the difference was statistically significant(P<0.05).Conclusion HDAC1,HDAC7,and ZNF191 are highly expressed in nasopharyngeal carcinoma tissue,closely related to tumor staging and lymph node metastasis,and can significantly increase the risk of recurrence and metastasis.