血清ESM-1、TuM2-PK水平与直肠癌患者病情严重程度和预后的关系

Relationship Between Serum ESM-1,TuM2-PK and Severity of Disease and Prognosis of Patients with Rectal Cancer

目的探讨直肠癌患者血清ESM-1、TuM2-PK水平及临床意义。方法选取直肠癌患者120例,入院时TNM分期,Ⅰ~Ⅱ期18例、Ⅲ期58例、Ⅳ期44例,根据实体瘤治疗疗效评价标准评估预后分为预后良好组30例,预后不良组90例。比较不同临床分期血清ESM-1、TuM2-PK水平,并分析其与临床分期的相关性,比较不同预后患者入院时、化疗1个周期后、化疗2个周期后血清ESM-1、TuM2-PK水平,并分析联合指标检测对直肠癌患者预后的判断价值。结果不同分期入院时患者血清ESM-1、TuM2-PK水平比较,P<0.05;入院时血清ESM-1、TuM2-PK水平与TNM分期成正比(γ=0.782,P<0.001;γ=0.320,P<0.001);不同预后患者入院时血清ESM-1、TuM2-PK水平比较,P>0.05,化疗1、2个周期后,预后不良组患者血清ESM-1、TuM2-PK水平均高于预后良好组,P<0.05;化疗1、2个周期后,血清ESM-1、TuM2-PK水平联合预测AUC为0.926、0.991,敏感度为94.4%、98.9%,特异度为83.3%、93.3%。结论直肠癌患者血清ESM-1、TuM2-PK水平与临床分期和预后有一定相关性,并且联合检测可以有效预测患者预后。

Objective To investigate the serum ESM-1 and TuM2-PK levels and their clinical significance in patients with rectal cancer.Methods A total of 120 patients with rectal cancer were selected.According to the TNM staging at admission,they were divided into stageⅠ~Ⅱ(n=18),stageⅢ(n=58),and stageⅣ(n=44).According to the prognosis evaluated by the Response Evaluation Criteria in Solid Tumors,they were divided into a good prognosis group(n=30)and a poor prognosis group(n=90).The levels of serum ESM-1 and TuM2-PK in patients with different clinical stages were compared,and their correlation with clinical stages was analyzed.The levels of serum ESM-1 and TuM2-PK in patients with different prognosis at admission,after 1 cycle of chemotherapy,and after 2 cycles of chemotherapy were compared,and the prognostic value of combined detection indicators in patients with rectal cancer was analyzed.Results The levels of serum ESM-1 and TuM2-PK in different stages were compared at admission,P<0.05;Serum ESM-1 and TuM2-PK levels were proportional to TNM stage at admission(γ=0.782,P<0.001;γ=0.320,P<0.001);The serum ESM-1 and TuM2-PK levels of patients with different prognosis were compared at admission,P>0.05.After 1 and 2 cycles of chemotherapy,the combined prediction of serum ESM-1 and TuM2-PK levels was 0.926 and 0.991,the sensitivity was 94.4%and 98.9%,and the specificity was 83.3%and 93.3%.Conclusion Serum ESM-1 and TuM2-PK levels are correlated with clinical stage and prognosis,and combined detection can effectively predict the prognosis of patients with rectal cancer.