单向式全胸腔镜肺叶切除术对非小细胞肺癌患者围术期指标及预后的影响

The Impact of Unidirectional Thoracoscopic Lobectomy on Perioperative Indicators and Prognosis in Non-small Cell Lung Cancer Patients

目的探讨单向式全胸腔镜肺叶切除术对非小细胞肺癌(NSCLC)患者围术期指标及预后的影响。方法选择90例NSCLC患者,随机数字表法分为两组,各45例,对照组行开放式肺叶切除术,观察组行单向式全胸腔镜肺叶切除术,比较两组围术期指标及预后。结果观察组手术时间、引流时间短于对照组,出血量、引流量少于对照组(P<0.05);观察组术后24 h的血清细胞角质蛋白19片段抗原21-1、糖类抗原50、癌胚抗原水平低于对照组(P<0.05);观察组并发症发生率低于对照组(P<0.05)。两组术后1年生存率相比,差异无统计学意义(P>0.05)。结论单向式全胸腔镜肺叶切除术对NSCLC患者围术期指标具有改善作用,同时能降低血清肿瘤标志物水平和减少并发症,但对近期预后无明显影响。

Objective To investigate the effects of unidirectional total thoracoscopic lobectomy on perioperative indexes and prognosis of patients with non-small cell lung cancer(NSCLC).Methods 90 patients with NSCLC were randomly divided into 2 groups with 45 cases in each group.The control group underwent open lobectomy and the observation group underwent unidirectional thoracoscopic lobectomy.The perioperative indexes and prognosis of the 2 groups were compared.Results The operation time and drainage time in the observation group were shorter than those in the control group,and the blood loss and drainage volume were less than those in the control group(P<0.05).The levels of keratin19 fragment antigen 21-1,carbohydrate antigen 50 and carcinoembryonic antigen in the observation group were lower than those in the control group 24h after operation(P<0.05).The complication rate of the observation group was lower than that of the control group(P<0.05).There was no significant difference in the 1-year survival rate between the 2 groups(P>0.05).Conclusion Unidirectional thoracoscopic lobectomy can improve perioperative indexes of NSCLC patients,reduce serum tumor markers and complications,but has no significant effect on short-term prognosis.