老年肺癌患者化疗前后焦虑及抑郁现状分析

Analysis of anxiety and depression in elderly patients with lung cancer before and after chemotherapy

目的:研究老年肺癌患者化疗前后焦虑及抑郁情况。方法:选择2022年1月至2024年2月在沈阳市某三甲医院肿瘤科治疗的确诊为肺癌且可进行化疗的老年患者168例为研究对象。统计肺癌患者化疗前后焦虑自评量表(SAS)、抑郁自评量表(SDS)评分情况。患者一般资料与化疗前后的SDS和SAS评分相关性分析采用Spearman秩相关检验。结果:肺癌患者化疗后SDS、SAS评分均明显高于化疗前,化疗后抑郁患者和焦虑患者比例也明显高于化疗前,差异均有统计学意义(P<0.05)。Spearman秩相关检验结果显示,肺癌患者化疗前后SDS和SAS评分升高和性别、病理分型、化疗周期、合并基础疾病、呼吸系统症状有低相关性(P<0.05)。结论:化疗增加老年肺癌患者焦虑和抑郁比例,性别、病理分型、化疗周期、合并基础疾病、呼吸系统症状与焦虑和抑郁发生有低相关性。

Objective:To investigate the anxiety and depression of elderly patients with lung cancer before and after chemotherapy.Methods:A total of 168 elderly patients diagnosed with lung cancer and eligible for chemotherapy in a Grade A tertiary hospital in Shenyang from Jan 2022 to Feb 2024 were selected as the study subjects.The basic data,self-rating depression scale(SDS),and self-rating anxiety scale(SAS)scores before and after chemotherapy were collected.The Spearman rank correlation test was used to analyze the correlation of the general data of patients with SDS and SAS scores before and after chemotherapy.Results:SDS and SAS scores of lung patients after chemotherapy were significantly higher than those before chemotherapy(P<0.05).The proportion of patients with depression and anxiety after chemotherapy was also significantly higher than that before chemotherapy(P<0.05).Results of Spearman's rank correlation test showed that,the increase of SDS and SAS scores was correlated with gender,pathological type,chemotherapy cycle,combined underlying diseases,and respiratory symptoms(P<0.05).Conclusions:Chemotherapy increases the proportion of anxiety and depression in elderly patients with lung cancer.Gender,pathological type,chemotherapy cycle,combined underlying diseases,and respiratory system symptoms are correlated with the occurrence of anxiety and depression.