睡眠时长与高尿酸血症关联的Meta分析

Meta-analysis of the association between sleep duration and hyperuricemia

目的:通过整合目前的流行病学数据,探究睡眠时长与高尿酸血症之间的剂量-反应关系。方法:在PubMed、Embase、Web of Science以及PsycINFO数据库中检索截至2023年6月6前符合纳入标准的观察性研究。使用比值比(OR)作为效应量,并基于随机效应模型进行合并。使用限制立方样条模型进行剂量-反应Meta回归分析。结果:经筛选,本研究纳入了来自7项横断面研究的9个独立样本,共计57 233名参与者,其中9 861(17.2%;95%CI:16.9%~17.5%)人确诊高尿酸血症。质量评估显示其中5项为高质量研究,2项研究为中等质量。Egger检验提示显著异质性,故采用随机效应模型合并。与正常睡眠时长(6~8 h)相比,短睡眠时长(<6 h)的合并OR值为1.12(95%CI:1.02~1.22),长睡眠时长(≥8 h)的合并OR值为1.05(95%CI:0.94~1.18)。亚组分析表明,平均体质量指数较高的人群中,短睡眠时长与高尿酸血症的正相关性更强。剂量-反应Meta分析显示,睡眠时长与高尿酸血症风险之间存在近似L形的关联,其拐点出现在7.5 h处。结论:睡眠时间过短与高尿酸血症风险增高显著相关,而睡眠时间过长与高尿酸血症无显著关联。本研究建议人们每晚睡眠≥7.5 h以降低高尿酸血症风险。

Objective:To investigate the dose-response relationship between sleep duration and hyperuricemia by integrating currently available epidemiological data.Methods:PubMed,Embase,Web of Science,and PsycINFO were searched up to June 6,2023,for eligible observational studies.Odds ratios(OR)were used as the effect sizes and combined based on random-effects models.A restricted cubic spline model was adopted in the dose-response meta-analysis.Results:Nine independent samples from seven cross-sectional studies with 57233 participants were included.Among them,9861(17.2%;95%CI:16.9%-17.5%)hyperuricemia cases were identified.The quality assessment showed that five studies were of high quality,and two were of moderate quality.Egger tests suggested significant heterogeneity;thus,random-effects models were used.Compared with normal sleep duration(6-8 h),the combined OR for short sleep duration(<6 h)was 1.12(95%CI:1.02-1.22),and the combined OR for long sleep duration(≥8 h)was 1.05(95%CI:0.94-1.18).Subgroup analyses indicated a stronger positive association between short sleep duration and hyperuricemia among thepopulation with higher body mass index (BMI). The dose-response meta-analysis showed an approximatelyL-shaped association between sleep duration and hyperuricemia risk, with the inflection pointat 7. 5 h. Conclusion: Short sleep duration was significantly associated with a higher risk of hyperuricemia,whereas long sleep duration was not. This study suggests people sleep for ≥7. 5 h/night tomaintain a low hyperuricemia risk.