生脉散治疗慢性!竭的临床应用现状

Current status of clinical application of Shengmaisan in the treatment of chronic heart

慢性心力衰竭(CHF)有较高的发病率和死亡率,中医运用生脉散在治疗CHF方面具有独特的优势。生脉散可以改善心力衰竭患者的临床症状,提高生活质量,其主要通过抑制神经内分泌系统、抑制免疫炎症反应、抑制心肌纤维化、抑制心肌细胞凋亡、抗氧化应激反应、降低Ca^(2+)泄露增加心肌收缩力等多种途径来发挥作用。本文对近年来生脉散治疗CHF进行论述,以期能更好地应用于临床。

Chronic heart failure(CHF)has high morbidity and mortality.The application of Shengmaisan in traditional Chinese medical science has unique advantage in the treatment of chronic heart failure.Shengmaisan can improve the clinical symptoms and quality of life of patients with heart failure.It mainly plays its role through inhibition of neuroendocrine system,inhibition of immune inflammation response,inhibition of myocardial fibrosis,inhibition of cardiomyocyte apoptosis,anti-oxidative stress response,reduced Ca^(2+)leakage and increase myocardial contractility.This article discusses the treatment of chronic heart failure with Shengmaisan in recent years,in order to better clinical application.