铁死亡在心肌缺血再灌注损伤的作用机制及中医药研究现状

Research status of iron death on myocardial ischemia reperfusion injury and research progress of traditional Chinese medicine

铁死亡是一种铁依赖性和脂质过氧化驱动的调节性细胞死亡,与铁、脂质、氨基酸代谢密切相关,并且还受多种信号通路的影响。近些年研究表明铁死亡在心肌缺血再灌注损伤(MIRI)的发生发展具有十分重要的作用,MIRI是一种涉及多种细胞病理生理过程的现象,常发生于急性心肌梗死、冠心病和心搏骤停复苏等心血管不良事件后。中医药因其天然来源和疗效,在治疗MIRI方面具有独特的优势。本文对铁死亡在MIRI各病理环节中的作用及以铁死亡为靶点的中医药干预MIRI的研究现状进行了综述,以期从铁死亡角度为中医药防治MIRI提供新思路和方法。

Ferroptosis is regulatory cell death driven by iron dependence and lipid peroxidation,which is closely related to iron,lipid and amino acid metabolism,and is also affected by a variety of signaling pathways.Recent studies have shown that ferroptosis plays an important role in the occurrence and development of myocardial ischemia-reperfusion injury(MIRI).MIRI is a phenomenon involving a variety of cellular pathophysiological processes and cellular signaling pathways,which often occurs after adverse cardiovascular events such as acute myocardial infarction,coronary heart disease,and cardiac arrest and resuscitation.Traditional Chinese medicine has unique advantages in the treatment of MIRI due to its natural source and efficacy.This article reviews the role of ferroptosis in the pathological links of MIRI and the research status of traditional Chinese medicine intervention with ferroptosis as the target,in order to provide new ideas and methods for the prevention and treatment of MIRI from the perspective of ferroptosis.