中医药诱导铁死亡治疗消化系统肿瘤的研究现状

Research status of raditional Chinese medicine-induced ferroptosis for digestive system tumors

传统中医药与现代医学的手术、化疗、放疗等治疗手段相互配合,在消化系统肿瘤治疗中发挥了越来越重要的作用。中医药治疗消化系统肿瘤的机制涉及很多方面,其中一个重要的机制是诱导肿瘤细胞发生程序性死亡。铁死亡与二价铁和酯氧合酶催化的细胞膜上大量脂质过氧化物产生引起细胞死亡有关,与细胞氧化应激密切相关。本文对中医药通过诱导消化系统肿瘤细胞铁死亡发挥抗肿瘤作用的机制研究进行综述,以期为更好地开发利用中医药治疗消化系统肿瘤提供新思路。

Traditional Chinese medicine combinedwith modern medicine,such as surgery,chemotherapy,radiotherapy and others,play an increasingly important role in the treatment of digestive system cancers.The research on the therapeutic mechanism of traditional Chinese medicine for digestive system tumors involves many aspects.One of these mechanism is that traditional Chinese medicine caninducethe programmed cell death of cancer cells.Programmed cell death includes apoptosis,programmed necrosis,pyroptosis and ferroptosis.Ferroptosis is closely related to the cell death caused by the production of lipid peroxides which are catalyzed over ferric divalent and ester oxygenase on the cell membrane and the cell oxidative stress.In order to provide the new ideas for better development and utilization of traditional Chinese medicine in the treatment of digestive system cancers,this paper reviews the research progress on the anti-cancer mechanism of traditional Chinese medicine through inducing the cancer cell ferroptosis.