LINC00511在消化系统恶性肿瘤中的作用及治疗价值

Role of long intergenic non-coding RNA 00511 in human malignant tumors of the digestive system

目的分析LINC00511在消化系统恶性肿瘤发展过程中的作用及相关机制,以提示其作为新型生物标志物及治疗靶点的潜力。方法以“LINC00511、digestive system cancer、long non-coding RNA、tongue squamous carcinoma、esophagus cancer、gastric cancer、hepatocellular carcinoma、pancreatic cancer、colorectal cancer”为英文关键词,以“LINC00511、消化系统恶性肿瘤、长链非编码RNA、舌鳞癌、食管癌、胃癌、肝细胞癌、胰腺癌、结直肠癌”为中文关键词,检索PubMed及中国知网数据库相关文献,检索时间为2017年1月-2023年2月。纳入标准:(1)LINC00511在消化系统恶性肿瘤中的作用及相关机制;(2)LINC00511在消化系统恶性肿瘤预防和治疗中的应用。排除标准:(1)实验设计不完整的研究;(2)评论类的文献;(3)重复文献。共纳入文献44篇。结果研究证明LINC00511在消化系统恶性肿瘤中异常高表达,在部分肿瘤中的表达程度与临床分期及预后相关。实验中LINC00511异常增高可提高肿瘤细胞的增殖、迁移及侵袭能力,沉默LINC00511后细胞恶性生物学行为受到抑制。结论LINC00511与多种消化系统恶性肿瘤细胞恶性表型密切相关,有望作为分子靶点在肿瘤治疗中发挥作用。

Objective To analyze the role and mechanisms of LINC00511 in the development of digestive system malignant tumors,in order to suggest its potential as a novel biomarker and therapeutic target.Methods We searched relevant literature from January 2017 to February 2023 in the PubMed and CNKI databases with the keywords of"LINC00511,long non-coding RNA,digestive system cancer,tongue squamous carcinoma,esophagus cancer,gastric cancer,hepatocellular carcinoma,pancreatic cancer,colorectal cancer".Inclusion criteria:(1)the role and mechanisms of LINC00511 in digestive malignant tumors;(2)the application of LINC00511 in the prevention and treatment of digestive malignant tumors.Exclusion criteria:(1)studies with incomplete experimental design;(2)review article;(3)duplicate literature.A total of 44 papers were included in the literature.Results The study demonstrates that LINC00511 is abnormally highly expressed in malignant tumors of the digestive system,and in some tumors,the degree of its expression is correlated with clinical stage and prognosis.The abnormal increase of LINC00511 can improve the proliferation,migration and invasion ability of cancer cells,and the malignant biological behaviors of cells will be suppressed after silencing LINC00511.Conclusion LINC00511 is closely related to malignant phenotypes of various digestive system malignant tumors and is expected to play a role as a molecular target in tumor therapy.