利培酮联合氯丙嗪治疗精神分裂症的效果

Effect of Risperidone Combined with Chlorpromazine in the Treatment of Schizophrenia

目的:分析利培酮联合氯丙嗪治疗对精神分裂症患者甲状腺激素水平及血脂指标的影响。方法:按随机数字表法将我院2023年3月—2024年4月收治的82例精神分裂症患者分为观察组(利培酮联合氯丙嗪治疗,42例)和对照组(利培酮治疗,40例),比较两组临床疗效、血脂水平、甲状腺激素水平。结果:治疗后,观察组临床总有效率(92.86%)高于对照组(65.00%)(P<0.05);观察组低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、三酰甘油(TG)、促甲状腺激素(TSH)水平高于对照组,且高密度脂蛋白(HDL-C)、三碘甲腺原氨酸(T3)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)水平低于对照组(P<0.05)。结论:利培酮联合氯丙嗪治疗精神分裂症患者的效果良好,可有效改善其甲状腺激素水平及血脂指标。

Objective:To analyze the effect of risperidone combined with chlorpromazine on thyroid hormone level and blood lipid index in patients with schizophrenia.Methods:According to the random number table method,82 patients with schizophrenia admitted to our hospital from March 2023 to April 2024were divided into observation group(risperidone combined with chlorpromazine treatment,42 patients)and control group(risperidone treatment,40 patients).The clinical efficacy,blood lipid level and thyroid hormone level were compared between the two groups.Results:After treatment,the total effective rate of the observation group(92.86%)was higher than that of the control group(65.00%)(P<0.05).The levels of low density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triglyceride(TG)and thyroid stimulating hormone(TSH)in the observation group were higher than those in the control group,and the levels of high density lipoprotein(HDL-C),triiodothyronine(T3),free triiodothyronine(FT3)and free thyroxine(FT4)were lower than those in the control group(P<0.05).Conclusion:Risperidone combined with chlorpromazine has a good effect in the treatment of patients with schizophrenia,which can effectively improve their thyroid hormone levels and blood lipid indicators.