盐酸氨溴索联合乙酰半胱氨酸雾化吸入治疗老年慢性支气管炎的临床疗效

Clinical Efficacy of Ambroxol Hydrochloride Combined with Acetylcysteine Aerosol Inhalation in the Treatment of Elderly Patients with Chronic Bronchitis

目的:分析盐酸氨溴索联合乙酰半胱氨酸雾化吸入治疗老年慢性支气管炎的临床疗效。方法:选取我院2021年5月—2023年5月收治的122例老年慢性支气管炎患者,采用随机数字表法将患者分为参照组与实验组,每组61例。参照组给予盐酸氨溴索治疗,实验组联合乙酰半胱氨酸雾化吸入治疗。比较两组肺功能、免疫功能、血清炎性因子水平、临床疗效及不良反应。结果:治疗后,实验组FEV1、FEV1/FVC、PEF、IgG、IgM及IgA高于参照组,CRP、PCT以及IL-4水平低于参照组(P<0.05);实验组治疗总有效率为95.08%,高于参照组的80.33%(P<0.05);实验组不良反应发生率与参照组比较,差异无统计学意义(P>0.05)。结论:在老年慢性支气管炎患者治疗中,盐酸氨溴索联合乙酰半胱氨酸雾化吸入治疗更利于改善肺功能,提高免疫功能,降低机体炎症反应,且疗效确切,安全性高。

Objective:To analyze the clinical efficacy of ambroxol hydrochloride combined with acetylcysteine aerosol inhalation in the treatment of elderly patients with chronic bronchitis.Methods:A total of 122 elderly patients with chronic bronchitis admitted to our hospital from May 2021 to May 2023 were selected.The patients were divided into reference group and experimental group by random number table method,with 61 patients in each group.The reference group was treated with ambroxol hydrochloride,and the experimental group was combined with acetylcysteine aerosol inhalation.The lung function,immune function,serum inflammatory factor levels,clinical efficacy and adverse reactions were compared between the two groups.Results:After treatment,the FEV1,FEV1/FVC,PEF,IgG,IgM and IgA in the experimental group were higher than those in the reference group,and the levels of CRP,PCT and IL-4 were lower than those in the reference group(P<0.05).The total effective rate of treatment in the experimental group was 95.08%,which was higher than 80.33% in the reference group(P<0.05).There was no significant difference in the incidence of adverse reactions between the experimental group and the reference group(P>0.05).Conclusion:For elderly patients with chronic bronchitis,ambroxol hydrochloride combined with acetylcysteine aerosol inhalation therapy is more conducive to improving lung function,improving immune function,reducing the body's inflammatory response,and has definite efficacy and high safety.