甲氨蝶呤联合艾拉莫德治疗难治性类风湿关节炎的效果

Effect of Methotrexate Combined with Iguratimod in the Treatment of Refractory Rheumatoid Arthritis

目的:分析甲氨蝶呤(MTX)联合艾拉莫德(IT)治疗难治性类风湿关节炎(RA)的效果。方法:选取2019年7月—2022年12月我院收治的120例难治性RA病例为研究对象,根据不同治疗方式分组:I组40例、M组40例、IM组40例。I组予以IT治疗,M组予以MTX治疗,IM组为MTX+IT联合治疗。比较三组临床疗效、关节症状改善情况(关节疼痛率、关节肿胀率、晨僵时间)、骨代谢指标[25(OH)D、TPINP]。结果:治疗后,IM组总有效率高于I组、M组(P<0.05);IM组关节疼痛率、关节肿胀率低于I组、M组,晨僵时间短于I组、M组(P<0.05);IM组25(OH)D、TPINP水平优于I组、M组(P<0.05)。结论:MTX联合IT治疗难治性RA的临床疗效较为满意,能够明显改善患者关节症状及骨代谢指标,值得临床应用。

Objective:To analyze the effect of methotrexate(MTX)combined with iguratimod(IT)in the treatment of refractory rheumatoid arthritis(RA).Methods:A total of 120 patients with refractory RA admitted to our hospital from July 2019 to December 2022 were selected as the research objects.According to different treatment methods,they were divided into group I(40 patients),group M(40 patients)and group IM(40 patients).Group I was treated with IT,group M was treated with MTX,and group IM was treated with MTX+IT.The clinical efficacy,improvement of joint symptoms(joint pain rate,joint swelling rate,morning stiffness time)and bone metabolism indexes[25(OH)D,TPINP]were compared among the three groups.Results:After treatment,the total effective rate of IM group was higher than that of I group and M group(P<0.05).The joint pain rate and joint swelling rate in the IM group were lower than those in the I group and the M group,and the morning stiffness time was shorter than that in the I group and the M group(P<0.05).The levels of 25(OH)D and TPINP in IM group were better than those in I group and M group(P<0.05).Conclusion:The clinical efficacy of MTX combined with IT in the treatment of refractory RA is satisfactory,which can significantly improve the joint symptoms and bone metabolism indexes of patients,and is worthy of clinical application.