炎症指标在胃间质瘤中的应用价值

The value of inflammation-related indicators in gastric stromal tumor

目的探讨炎症指标在鉴别胃间质瘤以及评估胃间质瘤恶性潜能中的应用价值。方法选取2020年1月至2023年5月于武汉大学人民医院经手术治疗并确诊为胃间质瘤或胃平滑肌瘤的243例患者进行回顾性分析,比较两组的基线资料以及炎症指标,比较不同危险度胃间质瘤中的炎症指标,并比较≤2 cm胃平滑肌瘤以及极低危胃间质瘤的炎症指标。结果与胃平滑肌瘤的患者比较,胃间质瘤的患者年龄、PLR(血小板计数/淋巴细胞计数)、NLR(中性粒细胞计数/淋巴细胞计数)、SII(中性粒细胞计数×血小板计数/淋巴细胞计数)更高,LMR(淋巴细胞计数/单核细胞计数)更低,以及胃间质瘤直径更大(相比于≤2 cm),差异有统计学意义(P<0.05)。不同危险度胃间质瘤的患者炎症指标进行比较时,中高危胃间质瘤患者的PLR、NLR、SII更高,LMR更低,差异有统计学意义(P<0.05)。与≤2 cm胃平滑肌瘤相比,≤2 cm极低危胃间质瘤仅LMR差异有统计学意义(P<0.05)。结论与胃平滑肌瘤相比,胃间质瘤中的炎症反应更加复杂,且与恶变潜能高低相关,可通过炎症指标为胃间质瘤的鉴别以及恶性潜能评估提供指导依据。

Objective To research the value of inflammation-related indicators to distinguish gastric stromal tumor(GST)and assess malignant potential of GST.Methods The clinical data of 243 patients with GST or gastric leiomyoma(GL)which were retrospectively collected from Jan.2020 to May 2023.The baseline data and inflammation-related indicators were compared.The inflammation-related indicators of different malignant potential of GST were compared,and the inflammation-related indicators between the≤2 cm of GL and GST of very low malignant potential.Results Compared with the patients of GL,the patients of GST had older age,higher PLR(blood platelet count/lymphocyte count),higher NLR(neutrophil count/lymphocyte count),higher SII(neutrophil count×blood platelet count/lymphocyte count)and lower LMR(lymphocyte/monocyte),and the GST patients had larger diameter(comparing with the diameter of≤2 cm),the difference was statistically significant(P<0.05).When the inflammation-related indicators of different malignant potential of GST were compared,the GST patients of higher malignant potential had higher PLR,higher NLR,higher SII and lower LMR,the difference was statistically significant(P<0.05).There was only the LMR which had the statistically significant between the≤2 cm of GL and GST of very low malignant potential(P<0.05).Conclusion Compared with the GL,the GST has more complicated inflammatory reactions,and the inflammatory reaction is connected with the different malignant potential.We can use the inflammation-related indicators to distinguish GST and assess malignant potential of GST.