遗传谱系示踪技术与组织再生研究

Genetic Lineage Tracing and Tissue Regeneration

遗传谱系示踪技术已经成为揭示细胞起源和细胞命运决定的重要工具。近年来,该领域取得了较大的进展,研究者们已经成功构建并优化了一系列新型遗传谱系示踪技术,例如双同源重组酶介导的遗传谱系示踪技术。这些新兴技术为深入研究组织再生过程中的细胞增殖、分化以及转分化等现象提供了宝贵的工具。利用这些技术,研究者们已经成功揭示了一些组织再生过程中的关键细胞亚群和核心信号转导路径。该文致力于总结新型遗传谱系示踪技术的发展,以及它们在肝脏等组织再生研究中的应用,以此为细胞命运决定研究、组织再生研究以及再生医学的应用提供参考和启示。通过拓展这些新型遗传谱系示踪技术的使用,能够提高该领域的研究水平,优化和创新细胞命运决定的研究方法,从而推进再生医学的发展。

Genetic lineage tracing technology has become an important tool for uncovering cell origins and determining cell fate.In recent years,significant advancements have been made in this field,with researchers successfully constructing and optimizing a range of new genetic lineage tracing technologies,such as those mediated by dual recombinases.These emerging technologies provide invaluable tools for in-depth studies of cell proliferation,differentiation,and transdifferentiation phenomena during tissue regeneration.Using these technologies,researchers have successfully revealed key cell subpopulations and core signal transduction pathways during tissue regeneration.This article is dedicated to summarizing the development of these new genetic lineage tracing technologies and their applications in tissue regeneration research,such as in the liver regeneration,providing insights and references for studies on cell fate determination,tissue regeneration,and applications in regenerative medicine.Expanding the use of these novel genetic lineage tracing techniques can propel the research level in this field,and thereby optimize and innovate methods for studying cell fate determination,threreby advancing the development of regenerative medicine.