慢性阻塞性肺疾病频繁急性加重患者的生存质量及影响因素研究

Study on the status quo of quality of life and its influencing factors in patients with frequent acute exacerbation of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病(COPD)频繁急性加重患者的生存质量及其影响因素。方法选取252例诊断为COPD频繁急性加重的患者作为研究对象,收集其一般资料,并进行Charlson合并症指数(CCI)、Barthel指数(BI)以及COPD生活质量(CAT)评分;采用t检验和单因素方差分析自变量在不同特征的COPD频繁急性加重患者CAT得分上的差异,采用多重线性回归分析患者生存质量的影响因素。结果COPD频繁急性加重患者CAT评分(23.09±3.36)分,生存质量受COPD重度以上影响的患者比例为80.54%;文化程度、吸烟、病程、过去1年发病次数等10项变量的COPD频繁急性加重患者CAT评分比较,差异有统计学意义(P<0.05);多重线性回归分析结果显示,文化程度、CCI评分、病程、BI评分是COPD频繁急性加重患者生存质量的影响因素,模型F=9.155(P<0.001),调整R^(2)=0.382,模型拟合效果良好。结论COPD频繁急性加重患者生存质量处于偏低水平。

Objective To explore the quality of life and influencing factors of patients with frequent acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 252 patients diagnosed as frequent acute exacerbation of COPD were selected as study subjects.General information was collected.Charlson comorbidity index,Barthel index and COPD Assessment Test(CAT)were scored.t-tests and one-way ANOVA were used to analyze the differences in CAT scores of independent variables among AECOPD patients with different characteristics.Multiple linear regression analysis was applied to identify factors affecting patient survival quality.Results CAT score of the patients with frequent AECOPD was(23.09±3.35)points,with 80.54%of them suffering from severe quality of life.There were statistically significant differences in 10 variable scores for quality of life such as educational level,smoking,disease duration and frequency of onset in the past year between the patients with frequent AECOPD and control group(P<0.05).Multiple linear regression analysis showed that education level,Charlson comorbidity index score,disease duration and BI score were the influencing factors of quality of life in the patients with frequent AECOPD.The model had a good fitting effect with F=9.155(P<0.001)and adjusted R^(2)=0.382.Conclusion The survival quality of patients with frequent AECOPD is relatively low.