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前列腺癌骨转移机制研究进展

Research progress on the mechanisms behind prostate cancer bone metastasis
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摘要 前列腺癌骨转移是前列腺癌晚期阶段的突出表现,也是前列腺癌患者死亡的重要原因。本文综述了前列腺癌的恶性生理学行为及其骨转移机制,探讨了原发性前列腺癌产生具有骨转移表型的肿瘤亚群的机制,以及促进转移级联反应各个环节的因素。克隆进化理论揭示了前列腺癌细胞通过基因突变形成不同转移潜力的亚克隆;上皮-间质转化理论和基质金属蛋白酶在一定程度上揭示了肿瘤是如何进行局部侵袭和血管内渗;种子与土壤理论、循环肿瘤细胞理论解释了前列腺癌细胞在骨髓中的定植和微转移灶的形成;肿瘤微环境理论揭示了再激活的前列腺癌细胞如何与其他细胞协同形成转移灶。本文旨在为前列腺癌骨转移机制的进一步研究提供理论支持,并为临床治疗策略的优化提供参考。 Bone metastasis is a prominent manifestation in the advanced stages of prostate cancer and a significant cause of mortality among prostate cancer patients.This review examined the malignant physiological behavior of prostate cancer and its bone metastasis mechanisms.It explored the processes by which primary prostate cancer develops tumor subpopulations with bone metastatic phenotypes and the factors that promote various stages of the metastatic cascade.The clonal evolution theory explains how prostate cancer cells develop subclones with varying metastatic potentials through genetic mutations.The epithelial-mesenchymal transition(EMT)theory and the role of matrix metalloproteinases(MMPs)have been shown to elucidate the processes of local invasion and intravasation.The seed and soil theory,along with the circulating tumor cell(CTC)theory,have shed light on how prostate cancer cells colonize the bone marrow and form micrometastases.Additionally,the tumor microenvironment theory has described how reactivated prostate cancer cells interact with other cells to establish metastatic lesions.By reviewing related research findings,this paper aimed to provide theoretical support for further research on the mechanisms of prostate cancer metastasis and to offer references for the optimization of clinical treatment strategies.
作者 邓龙昕 周睿 吴涵 何煌 陈锐 DENG Longxin;ZHOU Rui;WU Han;HE Huang;CHEN Rui(Department of Urology,First Affiliated Hospital of Naval Medical University,Shanghai 200433,China;Department of Pathology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Department of Urology,Shanghai General Hospital,Shanghai Jiao Tong University,Shanghai 200080,China;First Clinical Medical College,Southern Medical University,Guangzhou 510515,China;Department of Urology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China)
出处 《西南医科大学学报》 2024年第6期481-487,共7页 Journal of Southwest Medical University
基金 国家自然科学基金面上项目(82272905) 上海市科学技术委员会自然科学基金面上项目(22ZR1478000)。
关键词 前列腺癌 骨转移 转移机制 克隆进化 上皮-间质转化 循环肿瘤细胞 肿瘤微环境 Prostate cancer Bone metastasis Metastatic mechanisms Clonal evolution Epithelial-mesenchymal transition Circulating tumor cells Tumor microenvironment
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