中枢性过度睡眠诊治进展

Progress in the diagnosis and treatment of central disorders of hypersomnolence

中枢性过度睡眠是日间过度思睡(excessive daytime sleepiness,EDS)的常见病因,严重影响患者日间功能。近年来,中枢性过度睡眠的诊断标准和治疗手段有较大的更新和进展。文章对常见中枢性过度睡眠疾病,如1型和2型发作性睡病、特发性过度睡眠、复发性过度睡眠的诊断标准和治疗进展进行了综述和解读,强调了夜间多导睡眠图(polysomnography,PSG)、脑脊液下丘脑分泌素-1(hypocretin-1,Hcrt-1)测定在诊断中枢性过度睡眠中的重要性。

Central disorders of hypersomnolence is a common cause of excessive daytime sleepiness(EDS),which significantly impairs the daytime function of these patients.In recent years,the diagnostic criteria and treatment methods of central disorders of hypersomnolence have been updated greatly.This article reviews and interprets the diagnostic criteria and treatment progress of common central disorders of hypersomnolence diseases,such as narcolepsy type 1,narcolepsy type 2,idiopathic hypersomnia and Kleine-Levin syndrome.The importance of nocturnal polysomnography(PSC)and cerebrospinal fluid hypocretin-1(Hcrt-1)determination in the diagnosis of central disorders of hypersomnolence were emphasized.