重视代谢相关脂肪性肝病相关肝细胞癌的基础与临床研究

Basic and clinical research of metabolism-related fatty liver disease-related hepatocellular carcinoma needs attention

代谢相关脂肪性肝病(MAFLD)已成为肝细胞癌(HCC)发病率上升的主要原因,而MAFLD相关HCC的具体分子机制尚未完全阐明。研究表明,代谢重编程、促癌信号通路激活、氧化应激、炎性反应和肠道微生物群失调是关键因素。目前MAFLD相关HCC缺乏特效药物治疗,免疫疗法并未显著改善MAFLD相关HCC患者预后。因此,对MAFLD相关HCC的基础与临床研究尤为紧迫和重要。本文将对MAFLD相关HCC最新的研究进展进行述评,旨在了解MAFLD向HCC进展中的作用机制,以期为MAFLD相关HCC的治疗和预后判断提供新的思路。

Metabolic-associated fatty liver disease(MAFLD)has become a major cause of the rising incidence of hepatocellular carcinoma(HCC).However,the specific molecular mechanisms underlying MAFLD-related HCC remain poorly understood.Research indicates that metabolic reprogramming,activation of oncogenic signaling pathways,oxidative stress,inflammatory responses,and dysbiosis of the gut microbiota are key factors.Currently,there are no effective drug treatments for MAFLD-related HCC,and immunotherapy has not significantly improved the prognosis of patients with this condition.Therefore,the basic and clinical research on MAFLD-related HCC is particularly urgent and important.This review will summarize the latest research on MAFLD-related HCC to elucidate the mechanisms of progression from MAFLD to HCC,aiming to provide new insights and strategies for the treatment and prognosis of MAFLD-related HCC.