正五聚蛋白3与癌症的相关性研究进展

Research progress of correlation between pentraxin 3 and cancer

正五聚蛋白3(PTX3)是先天免疫系统中的一种可溶性模式识别受体,同时属于急性期蛋白,其在免疫应答、炎性反应、细胞外基质重塑等方面具有重要作用。近年来的研究揭示了PTX3在多种癌症类型中的异常表达情况,及其在肿瘤局部微环境构成中的作用。PTX3通过调节癌症侵袭性和转移能力、新血管生成、肿瘤补体系统激活以及化疗药物耐药性的形成,显著影响癌症的发展过程。本文旨在概述PTX3的结构和生理功能,及其在乳腺癌、前列腺癌、肺癌等多发癌症中的研究进展,并突出PTX3作为一种癌症功能性血清标志物和治疗靶点的潜力,为癌症的临床治疗提供参考。

Pentraxin 3(PTX3)serves as a soluble pattern recognition receptor within the innate immune system,belonging to the family of acute phase proteins.Its multifaceted functions include pivotal roles in orchestrating immune responses,mediating inflammatory processes,and facilitating extracellular matrix remodeling.Recent studies have revealed the abnormal expression of PTX3 across diverse cancer phenotypes and its involvement in shaping the tumor microenvironments.PTX3 profoundly influences cancer progression by modulating tumor invasion,metastasis,angiogenesis,activation of the tumor complement system,and the development of chemotherapy resistance.This review aims to summarize the structural characteristics,physiological functions,and current research advancements pertaining to PTX3,particularly focusing on its implications in prevalent cancers such as breast,prostate,and lung cancer.Furthermore,we highlight the prospective utility of PTX3 as both a functional serum biomarker and a promising therapeutic target in cancer,thereby offering a reference for clinical strategies in cancer management.