特发性高钙尿症患儿血清PTH、25(OH)D水平与尿红细胞、尿钙的相关性分析

Correlation Analysis of Serum PTH,25(OH)D Levels with Urinary Red Blood Cells and Urinary Calcium in Children with Idiopathic Hypercalcemia

【目的】探讨特发性高钙尿症患儿血清甲状旁腺激素(PTH)、25-羟维生素D[25(OH)D]、钙、磷水平与尿红细胞、24 h尿钙的相关性。【方法】选取2019年1月至2023年12月本院收治的26例特发性高钙尿症患儿(观察组),另外选取在本院进行体检的33例健康志愿者作为对照组。比较两组血清PTH、25(OH)D、磷、钙水平,分析观察组患儿尿红细胞、24 h尿钙水平与血清PTH、25(OH)D、磷、钙水平的相关性。【结果】观察组血清PTH、25(OH)D水平高于对照组,差异有统计学意义(P<0.05);两组血清磷、钙水平比较,差异无统计学意义(P>0.05)。Pearson相关性分析显示:观察组PTH水平与尿红细胞、24 h尿钙呈正相关(r=0.877、0.717,均P<0.01);血清25(OH)D水平与尿红细胞、24 h尿钙呈正相关(r=0.837、0.746,均P<0.01);血清磷与尿红细胞、24 h尿钙无相关性(P>0.05);血清钙与尿红细胞、24 h尿钙无相关性(P>0.05)。【结论】特发性高钙尿症患儿血清PTH、25(OH)D水平明显升高,其与尿钙及血尿程度呈正相关。

【Objective】To investigate the correlation of serum parathyroid hormone(PTH),25-hydroxyvitamin D[25(OH)D],calcium and phosphorus levels with urinary red blood cells and urinary calcium at 24 h in children with idiopathic hypercalcemia.【Methods】A total of 26 children with idiopathic hypercalcemia admitted to our hospital from January 2019 to December 2023(the observation group)were selected,and 33 healthy volunteers who underwent physical examination in our hospital were selected as the control group.The serum levels of PTH,25(OH)D,phosphorus and calcium were compared between the two groups,and the correlation between urinary red blood cells and 24 h urinary calcium levels and serum PTH,25(OH)D,phosphorus and calcium levels in the observation group was analyzed.【Results】The levels of serum PTH and 25(OH)D in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in serum phosphorus and calcium levels between the two groups(P>0.05).Pearson correlation analysis showed that PTH level in the observation group was positively correlated with urinary red blood cells and 24 h urinary calcium(r=0.877,0.717,P<0.01).Serum 25(OH)D levels were positively correlated with urinary red blood cells and 24 h urinary calcium(r=0.837,0.746,P<0.01).There was no correlation between serum phosphorus and urinary red blood cells and urinary calcium at 24 h(P>0.05).There was no correlation between serum calcium and urinary red blood cells and urinary calcium at 24 h(P>0.05).【Conclusion】The serum levels of PTH and 25(OH)D were significantly increased in children with idiopathic hypercalcemia,which was positively correlated with urinary calcium and hematuria.