中药配方油膏改善尿毒症皮肤瘙痒的疗效观察

目的研究中药配方调制的外用油膏改善尿毒症皮肤瘙痒的临床疗效。方法通过“透析患者14项尿毒症皮肤瘙痒量表”筛选出本院维持性血液透析伴尿毒症皮肤瘙痒患者60例,随机分为观察组和对照组,每组30例。观察组接受西医基础治疗联合中药配方调制的油膏治疗,对照组接受西医基础治疗联合无中药配方的基础油膏治疗,疗程4周。采用PASW Statistics 18软件分析两组患者治疗前后在瘙痒积分、总有效率及生化指标上的变化。结果治疗前两组患者皮肤瘙痒积分比较,差异无统计学意义(P>0.05);治疗后,两组患者的瘙痒积分差异均有统计学意义(P<0.05),且观察组的瘙痒积分低于对照组,总有效率高于对照组,差异有统计学差异(P<0.05);两组患者生化指标在治疗前后无显著变化(P>0.05)。结论中药配方油膏能有效改善尿毒症患者的皮肤瘙痒症状,且效果优于无中药成分的基础油膏,值得在临床推广使用。

Objective To investigate the clinical efficacy of a traditional Chinese medicine(TCM)formula-based ointment in improving skin itching in patients with uremic pruritus.Methods A total of 60 patients with maintenance hemodialysis and uremic pruritus from our hospital were selected using the"14-item uremic pruritus scale for dialysis patients"and randomly divided into an observation group and a control group,with 30 cases in each group.The observation group received basic Western medical treatment combined with a TCM formula-based ointment,while the control group received basic Western medical treatment combined with a basic ointment without TCM formula.The treatment course was 4 weeks.The changes in itching scores,total effective rate,and biochemical indicators before and after treatment in both groups were analyzed using PASW Statistics 18 software.Results Before treatment,there was no significant difference in skin itching scores between the two groups(P>0.05);after treatment,the itching scores of both groups showed significant differences(P<0.05),and the observation group had lower itching scores and higher total effective rate than the control group,with significant differences(P<0.05);there were no significant changes in biochemical indicators before and after treatment in both groups(P>0.05).Conclusion The TCM formula-based ointment can effectively improve the skin itching symptoms of patients with uremia,and its effect is better than that of the basic ointment without TCM components,making it worth promoting for clinical use.