肺炎克雷伯菌异质性耐药研究进展

Research progress on heteroresistance of Klebsiella pneumoniae

肺炎克雷伯菌是一种常见的机会性致病菌,其对多种抗生素的耐药性给感染的治疗提出了重大挑战。近年来,越来越多异质性耐药的肺炎克雷伯菌被报道,异质性耐药即同源的细菌群体中存在着对某种特定的抗生素表现出不同敏感性的克隆亚群,异质性耐药往往与感染治疗失败和复发相关,肺炎克雷伯菌异质性耐药现象不容忽视。然而,在目前发表的文献中关于肺炎克雷伯菌异质性耐药的全面信息仍很少,临床医生对肺炎克雷伯菌异质性耐药现象的出现重视不足。因此,本文针对肺炎克雷伯菌异质性耐药的定义、检测方法、各种可用抗生素的异质性耐药的研究现状和治疗方案进行综述,以期为临床治疗异质性耐药的肺炎克雷伯菌感染提供有价值的参考。

Klebsiella pneumoniae is a common opportunistic pathogen,and its resistance to multiple antibiotics poses a major challenge to the treatment of infection.In recent years,more and more heteroresistant Klebsiella pneumoniae have been reported.Heterogeneous resistance means that there are clonal subpopulations in the homologous bacterial population that show different sensitivities to a specific antibiotic.Heterogeneous resistance is often associated with treatment failure and recurrence of infection.The phenomenon of heterogeneous resistance in Klebsiella pneumoniae cannot be ignored.However,there is still little comprehensive information on the heteroresistance of Klebsiella pneumoniae in the currently published literature,and clinicians do not pay enough attention to the emergence of heteroresistance of Klebsiella pneumoniae.Therefore,in this article,the definition,detection methods,research status and treatment options of heteroresistance of Klebsiella pneumoniae to various antibiotics are reviewed,in order to provide a valuable reference for the clinical treatment of heteroresistant Klebsiella pneumoniae infection.