布地奈德雾化吸入联合阿奇霉素治疗小儿支原体肺炎的有效性及对患儿血清免疫球蛋白水平的影响

Efficacy of Budesonide Nebulization Inhalation Combined with Azithromycin in the Treatment of Mycoplasma Pneumoniae Pneumonia in Children and its Impact on Serum Immunoglobulin Levels

目的探讨布地奈德雾化吸入联合阿奇霉素治疗小儿支原体肺炎(MPP)的效果。方法选取2021年4月—2023年12月贵阳市第二人民医院收治的92例MPP患儿为研究对象,按随机数字表法将其分为对照组和观察组,每组46例。对照组采用阿奇霉素治疗,观察组在此基础上采用布地奈德雾化吸入治疗。对比两组患儿的临床疗效、血清免疫球蛋白水平、炎症指标及安全性。结果观察组的治疗总有效率为95.65%,高于对照组的82.61%,差异有统计学意义(P<0.05)。治疗后,观察组的免疫球蛋白M、免疫球蛋白A及免疫球蛋白G水平均低于对照组,组间差异有统计学意义(P<0.05);观察组的C反应蛋白、白细胞计数、降钙素原水平均低于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论布地奈德雾化吸入联合阿奇霉素可增强MPP的治疗效果,改善患儿血清免疫蛋白球水平,减轻炎症,促进病情转归,且安全有效。

Objective To investigate the effect of budesonide nebulization inhalation combined with azithromycin in the treatment of mycoplasma pneumoniae pneumonia(MPP)in children.Methods Ninety-two children with MPP treated in the Second People's Hospital of Guiyang City from April 2021 to December 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 46 cases in each group.The control group was treated with azithromycin,and the observation group was treated with budesonide nebulization inhalation.The control group received azithromycin,while the observation group received budesonide nebulized inhalation.The clinical efficacy,serum immunoglobulin levels,inflammatory indicators and safety of the two groups were compared.Results The total effective rate of the observation group was 95.65%,which was higher than 82.61% of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of immunoglobulin M,immunoglobulin A and immunoglobulin G in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05);the levels of C-reactive protein,white blood cell count and procalcitonin in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Budesonide nebulization inhalation combined with azithromycin can enhance the therapeutic effect of MPP,improve the level of serum immunoglobulin,reduce inflammation,promote the outcome of the disease,and is safe and effective.