乌司他丁联合持续性血液净化治疗对脓毒症急性肺损伤患者的效果观察

Effect of Ulinastatin Combined with Continuous Blood Purification in the Treatment of Septic Patients with Acute Lung Injury

目的分析乌司他丁联合持续性血液净化治疗对脓毒症急性肺损伤患者的应用效果。方法回顾性分析2022年12月—2023年12月滨州医学院第一临床学院收治的160例脓毒症急性肺损伤患者的临床资料,按治疗方式不同将其分为对照组和观察组,每组80例。对照组采用持续性血液净化治疗,观察组在对照组基础上采用乌司他丁治疗。对比两组患者的血气分析指标、生理健康状态、炎性因子水平。结果治疗后,观察组急性生理学与慢性健康状况评分Ⅱ评分为(20.05±2.18)分,低于对照组的(26.12±3.15)分,差异有统计学意义(P<0.05);观察组血二氧化碳分压、血氧分压、氧合指数水平均高于对照组,呼吸频率低于对照组,组间差异有统计学意义(P<0.05);观察组人高迁移率族蛋白B1、肿瘤坏死因子及白细胞介素、超敏C反应蛋白水平均低于对照组,组间差异有统计学意义(P<0.05)。结论对于脓毒症急性肺损伤患者,采用持续性血液净化联合乌司他丁治疗,可有效减轻其炎症反应,改善患者血气分析指标状况,提高其生理健康状态。

Objective To analyze the effect of ulinastatin combined with continuous blood purification in the treatment of septic patients with acute lung injury.Methods The clinical data of 160 patients with acute lung injury from sepsis admitted to the First Clinical College of Binzhou Medical University from December 2022 to December 2023 were retrospectively analyzed.According to different treatment methods,they were divided into a control group and an observation group,with 80 cases in each group.The control group was treated with continuous blood purification,and the observation group was treated with ulinastatin on the basis of the control group.Blood gas analysis indicators,physiological health status and inflammatory factors were compared between the two groups.Results After treatment,the Acute Physiology and Chronic Health Evaluation Ⅱ score of the observation group was(20.05±2.18)points,which was lower than(26.12±3.15)points of the control group,and the difference was statistically significant(P<0.05);the blood partial pressure of carbon dioxide,blood partial pressure of oxygen and oxygenation index in observation group were higher than those in control group,and the respiratory rate was lower than that in control group,and the differences between the groups were statistically significant(P<0.05);the levels of high mobility group protein B1,tumor necrosis factor,interleukin and hypersensitive C-reactive protein in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion For patients with acute lung injury due to sepsis,continuous blood purification combined with ulinastatin therapy can effectively reduce the inflammatory response,improve the blood gas analysis indicators status of patients,and improve their physiological health status.