宫颈癌前病变与人乳头瘤病毒及鳞状细胞抗原相关研究

Study on the correlation between cervical precancerous lesions,human papilloma virus infection and squamous cell antigen

目的研究宫颈癌前病变与人乳头瘤病毒(HPV)感染、鳞状细胞抗原(SCC)之间的相关性。方法选择2023年4月至2024年1月本院收治的120例宫颈病变患者及在本院治疗的宫颈炎患者(对照组)75例作为研究对象,分析120例宫颈病变患者的相关资料,按不同的病情分为宫颈癌组(45例)、癌前病变组(75例),所有参与者均开展HPV检测、SCC检测,对比3组HPV阳性率、HPV病毒载量、SCC阳性率及SCC水平,并用Pearson相关性检验,分析宫颈癌前病变与HPV感染、SCC之间的关系。结果HPV阳性率相比,宫颈癌组93.3%明显高于癌前病变组88.0%、对照组20.0%,癌前病变组又高于对照组(P<0.05),且HPV病毒载量宫颈癌组明显高于癌前病变组、对照组(P<0.05);SCC阳性率相比,宫颈癌组91.1%明显高于癌前病变组80.0%、对照组26.8%,癌前病变组又高于对照组(P<0.05),且SCC水平宫颈癌组高于癌前病变组、对照组(P<0.05);经Pearson分析,HPV感染与宫颈癌前病变具有明显的相关性,呈正相关关系(P<0.05);经Pearson分析,SCC与宫颈癌前病变呈正相关关系(P<0.05)。结论针对宫颈癌前病变患者的HPV、SCC阳性率进行分析,发现当阳性率越高,宫颈癌前病情越严重,可以将其作为评估宫颈癌前病变的相关因素,指导临床治疗。

Objective To study the correlation between cervical precancerous lesions and human papilloma virus(HPV)infection and squamous cell antigen(SCC).Methods A total of patients with cervical lesions admitted to our hospital and 75 patients with cervicitis treated in our hospital(control group)from April 2023 to January 2024 were selected as research objects.Relevant data of 120 patients with cervical lesions were analyzed,and they were divided into cervical cancer group(45 cases)and precancerous lesion group(75 cases)according to different conditions.HPV detection and SCC detection were performed on all participants.HPV positive rate,HPV viral load,SCC positive rate and SCC level in the three groups were compared.pearson correlation test was used to analyze the relationship between cervical precancerous lesions,HPV infection and SCC.Results The positive rate of HPV in cervical cancer group was 93.3%higher than that in precancer group 88.0%and control group 20.0%,and the precancer group was higher than that in control group again(P<0.05),and HPV viral load in cervical cancer group was significantly higher than that in precancer group and control group(P<0.05).The SCC positive rate of cervical cancer group was 91.1%higher than that of precancer group 80.0%and control group 26.8%,and the precancer group was higher than the control group(P<0.05),and the SCC level of cervical cancer group was higher than that of precancer group and control group(P<0.05).By Pearson analysis,HPV infection was significantly correlated with cervical precancerous lesions(P<0.05).According to Pearson analysis,SCC was positively correlated with precancerous lesions(P<0.05).Conclusion The positive rate of HPV and SCC in patients with cervical precancer was analyzed,and it was found that the higher the positive rate was,the more serious the precancer was,which could be used as a relevant factor to evaluate cervical precancer and guide clinical treatment.