环境有机污染物的气相色谱/高分辨质谱分析

Environmental analysis of organic pollutants by gas chromatography coupled to high-resolution mass spectrometry

工业生产和人类生活活动导致大量化学品进入环境,进入环境的化学品会发生迁移转化等环境行为,对生态环境和人类健康造成潜在危害.环境污染物数量众多且包含大量未知化合物,传统的分析仪器受其分辨率和扫描速率的限制,不能满足对环境污染物全面筛查的需要.气相色谱-飞行时间质谱(GC-QTOF MS)和气相色谱-轨道离子阱质谱(GC-Orbitrap MS)拥有更高的分辨率及更高的灵敏度,已在环境分析领域发挥重要作用.本文对环境分析中基于GC-QTOF MS和GC-Orbitrap MS的研究进行了总结,归纳了基于GC-QTOF MS和GC-Orbitrap MS分析的常用样品前处理方法,探讨了GC-QTOF MS和GC-Orbitrap MS在不同环境基质中有机污染物靶向筛查、可疑化合物筛查以及非靶向筛查中的应用,有助于为环境基质中新污染物的识别和量化研究提供参考.

The extensive manufacturing and use of chemicals by human beings makes numerous chemicals ubiquitous in the environment.Many environmental behaviors of a variety of chemicals such as migration and transformation may occur in the environment,posing a threat to the ecology and human health.Due to the large number of environmental pollutants and the large number of unknown compounds,as well as the limits of low resolution and low scanning rate of traditional analytical instruments,traditional analytical techniques cannot meet the requirements for comprehensive screening of environmental organic pollutants.High resolution mass spectrometry,such as gas chromatography combined with Time-of-Flight mass spectrometry(GC-QTOF MS)and gas chromatography Orbitrap mass spectrometry(GC-Orbitrap MS),display higher resolution and higher sensitivity than that of traditional analytical instruments.They have played important roles in the field of environmental analysis.This review summarizes the research progress of environmental analysis of organic pollutants based on GC-QTOF MS and GC-Orbitrap MS.This review summarizes the pre-treatment methods based on GC-QTOF MS and GC-Orbitrap MS for the analysis of different environmental samples.Their applications in target analysis,suspect screening analysis and non-targeted analysis from the perspective of different environmental matrices were discussed.This study is helpful for future research on identification and quantifications of emerging contaminants in environment.