孕期全氟烷基化合物暴露对胎儿生长发育影响的研究进展

Research progress of perfluoroalkyl substances exposure during pregnancy and its effects on fetal growth

全氟烷基化合物(Perfluoroalkyl substances,PFASs)作为一种新型的有机污染物,可在环境中长期存在.孕期由于胎儿尚处在发育阶段,对环境污染物等风险因素格外敏感.大量流行病学研究在孕妇乳汁、血液、尿液中检测到PFASs存在,提示胎儿有暴露于PFASs的风险,并可能导致胎儿不良出生结局.本文综述了国内外关于PFASs在母婴人群中的暴露现状及其对母体及胎儿影响的研究进展,指出目前研究的发展趋势,以期为今后的研究提供参考.

Perfluoroalkyl substances(PFASs)are emerging organic pollutant that can persist in the environment.Due to the development stage,the fetus is particularly sensitive to environmental pollutants and other risk factors during pregnancy.Numerous epidemiological studies have detected the presence of PFASs in the milk,blood,and urine of pregnant women,suggesting a risk of fetal exposure to PFASs,which may lead to adverse fetal birth outcomes.In this paper,we reviewed the progress of latest studies on PFASs exposure and its biological effects on mothers and fetuses,summarized the current research trends and provide references for future studies.