H型血管在骨—血管偶联稳态维持作用的研究现状

Research progress on type H vessels in coupling angiogenesis and osteogenesis in bone homeostasis and diseases

作为高度血管化的组织,骨骼系统各项功能均由骨内血管系统支持,血管形成与骨形成在时空上存在密切联系。H型血管是一种具有特殊形态结构和功能的骨髓微血管,因其内皮细胞高表达血小板内皮细胞黏附分子-1(platelet endothelial cell adhesion molecule-1,PECAM-1/CD31)和内皮黏蛋白(endomucin,Emcn)而得名。H型血管是骨-血管偶联稳态维持的关键调控因素,可与骨祖细胞、成骨细胞、破骨细胞前体等相互作用,调节骨形成、骨重塑等骨生理活动,参与如骨质疏松症、骨关节炎等多种骨骼疾病的发生及进展。本文主要对H型血管在骨-血管偶联稳态维持及骨骼疾病中的最新研究现状进行综述。

As a highly vascularized tissue,the skeletal system can hardly perform its functions without the support from blood vesselsin bone,and angiogenesis is closely associated with osteogenesis spatially and temporally.Recent studies have identified a new type of mi-crovessels in bone marrow with distinct morphological,molecular,and functional characteristics,termed as type H vessels due to the highexpression of platelet endothelial cell adhesion molecule-1(PECAM-1/CD31)and endomucin(Emcn)in the endothelial cells.It was re-vealed that type H vessels were the key regulatory factors for the maintenance of angiogenesis-osteogenesis coupling,regulating physiologi-cal activities such as bone modeling and remodeling through interactions with osteoprogenitors,osteoblasts,and osteoclasts progenitors.Be-sides,type H vessels were also involved in the pathogenesis of various skeletal diseases,such as osteoporosis and osteoarthritis.This reviewaims to summarize the latest research progress on type H vessels and their role in bone disorders.