摘要
患者来源类器官是肿瘤研究的新兴体外模型,是能够高度保留患者肿瘤特征的体外肿瘤类似物,其保留了肿瘤内异质性及肿瘤间异质性,通过体外实验检验患者肿瘤对药物治疗的反应,指导肿瘤的精准治疗。本文总结患者来源类器官在前列腺癌、膀胱癌、肾癌3种常见泌尿系统肿瘤的药物敏感性检测、肿瘤标志物研究及新疗法验证中的应用,探索其在精准治疗临床研究中的价值及发展方向。
Patient-derived organoid is an emerging in vitro model in tumor research,highly preserving intratumoral and intertumoral heterogeneity,monitoring patients'response to drugs and other therapies,and guiding precision medicine choice for tumor treatment.This review described the application of patient-derived organoid in drug sensitivity test,cancer biomarkers,validation of new therapies in prostate cancer,bladder cancer,and renal cancer,exhibiting the role of patient-derived organoid in clinical tumor research.
作者
吴美静
练新荣
刘跃平
Wu Meijing;Lian Xinrong;Liu Yueping(Peking Union Medical College,Beijing 100730,China;Department of Radiation Oncology,Cancer Hospital and Institute,National Cancer Center/National Clinical Research Center for Cancer,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2024年第11期877-880,共4页
Chinese Journal of Urology
关键词
前列腺肿瘤
膀胱肿瘤
肾肿瘤
类器官
精准医学
Prostatic neoplasms
Urinary bladder neoplasms
Kidney neoplasmsO
rganoids
Precision medicine
