从肠道菌群微生态角度探讨“培土生金”法辨治肺癌的科学内涵

Scientific Connotations of "Reinforcing Earth for Generating Metal" in the Treatment of Lung Cancer from the Perspective of the Microecology of Intestinal Microbiota

“培土生金”是基于中医五行学说“虚则补其母”的治疗原则,以五行相生的原理,通过增强“土”脏腑(脾和胃)的功能,达到间接滋养“金”脏腑(肺和大肠)的效果。培土生金法应用于肺癌治疗中,可加强“土”脏腑的功能达到对“金”脏腑的治疗效果。肠道菌群组成和结构改变引起的代谢紊乱、炎症反应、免疫调节参与肺癌的发生发展,这与中医学“肺与大肠相表里”理论有相通之处。从肠道菌群微生态的角度,初步探讨肠道菌群失调致使肺癌发生的“土病及金”病机,以及以调整肠道菌群微生态平衡为途径的“培土生金”治法,提示以肠道菌群微生态平衡为目标的“培土生金”法在肺癌治疗中具有重要意义。

"Reinforcing earth for generating metal" is based on the treatment principle of the five-element theory of traditional Chinese medicine(TCM),which states that "reinforcing mother viscera for treating deficiency of child viscera".Based on the principle of inter-generating relationship in the five elements that earth generates metal,by strengthening the functions of the internal organs belonging to "earth"(spleen and stomach) to indirectly nourish the internal organs belonging to "metal"(lungs and large intestine).Using reinforcing earth for generating metal in the treatment of lung cancer,according to the principle of "reinforcing mother viscera for treating deficiency of child viscera",by strengthening the function of "earth" viscera,the treatment effect of "metal" viscera can be achieved.The metabolic disorder,inflammatory response,and immune regulation caused by the changes in the composition and structure of intestinal microbiota are involved in the occurrence and development of lung cancer,which is consistent with the theory of “the external and internal relationship between the lung and the large intestine” in TCM.From the perspective of intestinal microbiota microecology,the paper discusses the pathogenesis of "earth disease leads to metal disorders" that the gut microbiota dysbiosis causes lung cancer and the treatment method of "reinforcing earth for generating metal" by regulating the microecological balance of gut microbiota in lung cancer,suggesting the great significance of "reinforcing earth for generating metal" therapy aiming at microecological balance of gut microbiota in the treatment of lung cancer,in order to provide a different perspective for the treatment of lung cancer with TCM.