基于膳食抗炎指数的营养治疗对接受化疗的肺癌患者免疫功能、炎症因子、肿瘤相关疲劳及化疗不良反应的影响

Effects of dietary anti-inflammatory index based nutritional support on immune function,inflammatory factors,cancerrelated fatigue and chemotherapy toxicity in lung cancer patients receiving chemotherapy

目的探讨基于膳食抗炎指数的营养治疗对接受化疗的肺癌患者免疫功能、炎症因子、肿瘤相关疲劳及化疗不良反应的影响。方法选取2020年2月至2023年12月于空军军医大学唐都医院接受化疗的肺癌患者133例作为研究对象,依据选取时间不同,将2020年2月至2021年12月接受常规饮食管理的66例肺癌患者设立为对照组,将2022年1月至2023年12月接受基于膳食抗炎指数的营养治疗的67例肺癌患者设立为试验组。比较两组患者化疗前的营养状况、免疫功能、肿瘤疲乏、炎症因子,观察化疗期间的不良反应。结果在化疗1个周期后(T1)、化疗2个周期后(T2)、化疗4个周期后(T3)时点,试验组的总蛋白(TP)、白蛋白(ALB)、前白蛋白(PA)水平,CD4+T细胞、CD8+T细胞计数,以及CD4+/CD8+T细胞高于对照组,而超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)水平低于对照组(P<0.05)。在T3时点,试验组的肿瘤疲乏量表(CFS)评分的躯体疲乏、情感疲乏、认知疲乏维度得分及总分低于对照组(P<0.05)。试验组的白细胞减少、血小板减少,恶心呕吐及腹泻发生率均低于对照组(P<0.05)。结论基于膳食抗炎指数的营养治疗有助于改善接受化疗的肺癌患者的营养状况,并提高免疫功能和减轻肿瘤疲乏程度,对提高化疗效果具有积极作用。

Objective To investigate the effects of dietary anti-inflammatory index on immune function,inflammatory factors,cancer-related fatigue and chemotherapy toxicity in lung cancer patients receiving chemotherapy.Method A total of 133 lung cancer patients who received chemotherapy in Tangdu Hospital of Air Force Military Medical University from February 2020 to December 2023 were selected as the study objects.According to different selection times,66 lung cancer patients who received conventional diet management from February 2020 to December 2021 were set as the control group.A total of 67 patients with lung cancer who received nutritional support based on dietary anti-inflammatory index from January 2022 to December 2023 were selected as the experimental group.The nutritional status,immune function,cancer fatigue and inflammatory factors before chemotherapy were compared,and the toxic and side effects during chemotherapy were observed.Result At T_1,T_2 and T_3,TP,ALB,PA,CD4~+,CD8~+,CD4~+/CD8~+in observation group were higher than those in control group,while hs-CRP and IL-6 were lower than those in control group(P<0.05).At T_3 time point,the scores of physical fatigue,emotional fatigue and cognitive fatigue in the Cancer Fatigue Scale(CFS)of the experimental group were lower than those of the control group(P<0.05).The incidence of leukopenia,thrombocytopenia,nausea,vomiting and diarrhea in observation group were lower than those in control group(P<0.05).Conclusion Nutritional support based on dietary anti-inflammatory index can improve the nutritional status,immune function and reduce cancer fatigue in lung cancer patients treated with chemotherapy,which has a positive effect on improving the chemotherapy effect.