妇科恶性肿瘤患者肌肉减少症的研究进展

Progress in the study of sarcopenia in patients with gynecologic malignancies

肌肉减少症是一种与肌肉质量和力量减少及体力下降密切相关的综合征。由于妇科恶性肿瘤手术往往需要广泛的多脏器手术治疗,还可能伴随长期的放化疗和免疫治疗,导致妇科恶性肿瘤患者肌肉减少症发生率升高,严重影响患者的躯体功能、治疗效果和生活质量。同时,肌肉减少症会缩短妇科恶性肿瘤患者的无进展生存期,增加化疗不良反应和术后并发症的发生率。本文对妇科恶性肿瘤患者肌肉减少症进行综述,分别从筛查与评估方法、影响因素和非药物干预措施方面进行总结,旨在帮助临床医务人员更好地了解妇科恶性肿瘤患者肌肉减少症,为肌肉减少症制订有针对性的管理策略提供借鉴。

Sarcopenia is a syndrome closely associated with decreased muscle mass and strength as well as decreased physical strength.As gynecologic malignancy surgery often requires extensive multi-organ surgical treatment,which may also be accompanied by long-term radiotherapy and immunotherapy,leading to a higher incidence of sarcopenia in gynecologic malignancy patients,which seriously affects patients'somatic function,treatment outcome and quality of life.At the same time,there is increasing evidence that sarcopenia shortens progression-free survival,increases toxic side effects of chemotherapy and the incidence of postoperative complications in patients with gynecologic malignancies.This article reviews sarcopenia in patients with gynecologic malignancies,summarizing screening and assessment methods,influencing factors,and nonpharmacological interventions,respectively,with the aim of helping clinical staff to better understand sarcopenia in patients with gynecologic malignancies,and providing a reference for the development of targeted sarcopenia management strategies.