对亚甲基苯醌的不对称1,6-共轭加成反应研究进展

Research Progress in Asymmetric 1,6-Conjugated Addition Reactions of p-Quinone Methides

对亚甲基苯醌作为一种重要的醌类化合物,在极化为两性离子结构后活性很高,极易与亲核试剂发生1,6-共轭加成反应。从不同催化体系综述了对亚甲基苯醌参与不对称1,6-共轭加成反应的研究进展,并对生成的偕二芳基手性化合物的合成转化进行了总结,为相关药物的研发提供了指导。

As a kind of important quinone compounds,p-quinone methides exhibit high activity after polarization into a zwitterionic structure and are prone to undergo 1,6-conjugated addition reactions with nucleophilic reagents.In this paper,we review the research progress of asymmetric 1,6-conjugated addition reactions involving p-quinone methides from different catalytic systems,and summarize the synthesis and transformation of the generated chiral compounds with gem-diaryl groups,which provide guidance for the research and development of related medicines.