身心同治针法联合盐酸氟西汀治疗中风后抑郁对抑郁、神经功能及血清5-HT、NE、DA的影响

Effects of Body-Mind Acupuncture Combined with Fluoxetine Hydrochloride for Post-Stroke Depression on Depression,Neurological Function,and Serum 5-Ht,Ne,and Da

目的:身心同治针法联合盐酸氟西汀治疗中风后抑郁对抑郁、神经功能及血清5-HT、NE、DA的影响。方法:选取2023年1月~2024年1月徐州市中医院收治的中风后抑郁患者50例,采用随机数字表法分为对照组和治疗组各25例。在脑卒中常规治疗基础上,对照组单用盐酸氟西汀分散片,治疗组在对照组的基础上联合身心同治针法治疗。观察两组患者治疗前后临床疗效,HAMD量表、SDS量表、中医证候评分、FIM量表、MESSS量表、血清单胺类神经递质水平。结果:治疗后,治疗组总有效率高于对照组(P<0.05);治疗后,两组患者的HAMD-24、SDS、中医证候评分均较治疗前降低(P<0.05),且治疗组治疗后的HAMD-24、SDS、中医证候评分均低于对照组(P<0.05);治疗后,两组患者的FIM评分较治疗前升高,MESSS评分较治疗前降低(P<0.05),且治疗组治疗后的FIM评分高于对照组(P<0.05),MESSS评分低于对照组(P<0.05);治疗后,两组患者的5-HT、NE及DA水平均较治疗前升高(P<0.05),且治疗组治疗后的5-HT、NE及DA水平均高于对照组(P<0.05)。结论:身心同治针法联合盐酸氟西汀可有效改善中风后抑郁患者的抑郁、神经功能和生活质量,提高血清单胺类神经递质水平,值得临床推广应用。

Objective:Effects of body-mind acupuncture combined with fluoxetine hydrochloride in the treatment of post-stroke depres-sion on depression,neurological function and serum 5-HT,NE and DA.Methods:Fifty patients with post-stroke depression admitted to Xuzhou City Hospital of Traditional Chinese Medicine from January 2023 to January 2024 were selected and divided into 25 cases each in the control group and the treatment group by using the randomized numerical table method.On the basis of conventional stroke treat-ment,the control group was treated with fluoxetine hydrochloride dispersible tablets alone,and the treatment group was treated with combined body-mind acupuncture on the basis of the control group.Observe the clinical efficacy,HAMD scale,SDS scale,Chinese medicine evidence score,FIM scale,MESSS scale,blood monoamine neurotransmitter level before and after treatment in the two groups.Results:After treatment,the total effective rate of the treatment group was higher than that of the control group(P<0.05);after treatment,the HAMD-24,SDS,and MESSS scores of the patients in both groups were lower than those before treatment(P<0.05),and the HAMD-24,SDS,and MESSS scores of the treatment group were lower than those of the control group after treatment(P<0.05);af-ter treatment,the FIM scores of the patients in both groups were increased and MESSS scores decreased from before treatment(P<0.05),and the FIM scores of the treatment group were higher than those of the control group after treatment(P<0.05),and the MESSS scores were lower than those of the control group(P<0.05);after treatment,the levels of 5-HT,NE and DA of the patients in the two groups were higher than those of the patients before treatment(P<0.05),and the levels of 5-HT,NE and DA of the treatment group after treatment were higher than those of the control group(P<0.05).Conclusions:Body-mind acupuncture combined with fluoxetine hydro-chloride can effectively improve depression,neurological function and quality of life of post-stroke depressed patients,and increase blood monoamine neurotransmitter levels,which is worth clinical promotion and application.