噬血细胞综合征患者的铁代谢指标、细胞因子和肝功能的相关性

The Correlation of Iron Metabolism Indexes,Cytokines,and Liver Function in Patients with Hemophagocytic Syndrome

目的通过分析铁代谢指标、肝功能及细胞因子水平初步探讨噬血细胞综合征患者铁蛋白升高的原因。方法收集云南省第一人民医院2021年9月至2024年5月收治的噬血细胞综合征患者及对照组(铁蛋白升高的非噬血细胞综合征患者)各41例,进行铁代谢、细胞因子、肝功能检测,分析这些指标在2组间的差异及与铁蛋白的关系。结果噬血细胞综合征患者铁蛋白明显高于对照组(P<0.01),可溶性转铁蛋白受体明显低于对照组(P<0.01),细胞因子IL-4、IL-8、IL-10、IL-1β、IL-2、IFN-γ、TNF-α、TNF-β、IL-17A、IL-17F明显高于对照组(P<0.05),转氨酶、胆红素及乳酸脱氢酶明显高于对照组(P<0.01),铁蛋白与铁代谢指标无明显相关性,与细胞因子IL-4负相关,IL-8、IL-10正相关,与LDH、ALT、AST正相关(P<0.05)。结论噬血细胞综合征患者铁蛋白明显升高,但铁代谢指标与对照组无明显差异,噬血细胞综合征发病时多有明显炎症反应及肝损害,铁蛋白的升高与铁代谢指标无相关性,与炎症及肝损伤相关。

Objective To investigate preliminarily the causes of elevated ferritin in patients with he-mophagocytic syndrome by analyzing the iron metabolism indexes,liver function and cytokine levels.Methods 41 patients with the hemophagocytic syndrome and another 41 non-hemophagocytic syndrome patients with the elevated ferritin levels(as the control group)admitted to the First People’s Hospital of Yunnan Province from September 2021 to May 2024 were recruited for iron metabolism,cytokine and liver function tests,and the differences between these indexes and their relationship with the ferritin were analyzed.Results Patients with the hemophagocytic syndrome had the significantly higher levels of ferritin and lower levels of soluble transferrin receptor compared to the control group.Cytokines IL-4,IL-8,IL-10,IL-1β,IL-2,IFN-γ,TNF-α,TNF-β,IL-17A,and IL-17F were significantly higher than those in the control group,while transaminase,bilirubin,and lactate dehydrogenase were significantly higher than those in the control group.There was no significant correlation between ferritin and iron metabolism indicators,but it was negatively correlated with cytokine IL-4,positively correlated with IL-8 and IL-10,and positively correlated with LDH,ALT,and AST.Conclusion The ferritin of patients with hemophagocytic syndrome is significantly increased,but the iron metabolism process is not significantly different from that of the control group,and there are obvious inflammatory reactions and liver damage at the onset of the disease.The increase of ferritin is not correlated with iron metabolism indexes,but is related to the inflammation and liver damage.