外周血中NLR、PLR、FRA对骨折后骨质正常和骨质减少的影响

The Effects of NLR,PLR,and FRA in Peripheral Blood on Normal Bone Mass and Bone Loss after Fractures

目的探讨系统性炎症指标中的中性粒细胞/淋巴细胞比率、血小板/淋巴细胞比率、纤维蛋白/白蛋白比率,对骨折后骨质减少和骨质正常的影响。方法采用回顾性临床研究方法,所有数据均为昆明医科大学第一附属医院电子病例系统内公开信息和患者资料,期限为2023年1月至2023年9月,对病例库中骨折术后2652例患者病历资料,根据患者骨密度检测结果进行分组,分别为骨质减少组141例、骨质正常组79例。根据采集的相关数据分别把每组的相关信息NLR、PLR、FAR、性别、年龄、甘油三酯、血糖、血压等相关信息采用SPSS25.0软件进行分析。结果NLR、PLR、FAR在2组间差异无统计学意义(P>0.05),BMI、年龄和性别差异有统计学意义(P<0.05)。结论骨折后骨质减少的炎症反应可能与女性骨质疏松炎症因子不同。

Objective To investigate the effects of neutrophil/lymphocyte ratio,platelet/lymphocyte ratio,and fibrin/albumin ratio in systemic inflammatory markers on bone loss and normal bone function after fractures.Methods A retrospective study was conducted from January 2023 to September 2023 on the medical records of 2652 postoperative fracture patients publicly available in the electronic case system of the 1st Affiliated Hospital of Kunming Medical University.According to the results of bone density testing,patients were divided into two groups:141 patients with the reduced bone mass and 79 patients with the normal bone mass.According to the collected data,the relevant information of each group,including NLR,PLR,FAR,gender,age,triglycerides,blood glucose,blood pressure,etc,was analyzed using SPSS 25.0 software.Results There was no significant statistical difference in NLR,PLR,and FAR between the two groups(P>0.05).There were statistical differences in BMI,age and gender(P<0.05).Conclusion The inflammatory response of bone loss after the fracture may be different from the inflammatory factors of female osteoporosis.