昆明地区6462例成年人群骨代谢生化指标状况及影响因素分析

The Analysis of Biochemical Indexes of Bone Metabolism and Influencing Factors in 6462 Adult Population in Kunming Area

目的探讨受试人群骨代谢生化指标与性别、年龄、季节的关系及骨代谢生化指标间影响关系。方法回顾性分析2021年1月至2024年4月期间昆明医科大学第一附属医院体检中心6462例健康体检结果资料。收集所有受试对象的性别、年龄、25-羟基维生素D(25-OH-VD)、降钙素(CT)、N-端骨钙素(N-MID)、β-胶原降解产物(Beta-CrossLaps,β-CTX)体检资料指标。根据骨代谢生化指标参考值范围、性别、年龄、季节进行分组,应用SPSS29.0软件对数据进行总体水平分布统计,比较组间骨代谢生化指标水平的差异性,分析骨代谢生化指标水平相关性,探讨骨代谢生化指标水平影响因素。结果生化指标水平总体中位数25-OHVD 61.93(49.17,77.12)nmol/L、CT1.43(.53,3.01)pg/mL、N-MID16.0(12.8,20.2)ng/mL、β-CTX397.0(295.0,527.0)pg/mL。不同性别、年龄和季节的血清骨代谢生化指标水平差异有统计学意义(P<0.05)。N-MID与β-CTX呈显著正相关(rs=0.748)。性别、年龄和季节对25-OH-VD和N-MID的影响差异有统计学意义(P<0.05)。结论受试人群25-OH-VD水平总体中位数低于正常参考值范围,维生素D水平普遍不足,在低龄受试人群中更普遍,提示补充维生素D可能是重要的公共卫生问题。CT、N-MID和β-CTX水平总体中位数处于正常参考值范围,表明在这些指标上受试群体健康状况较好。性别和年龄是25-OH-VD、CT和N-MID水平的显著影响因素;季节是25-OH-VD、N-MID和β-CTX水平的显著影响因素。N-MID与β-CTX可能存在密切的生物学联系。

Objective To investigate the relationship between the biochemical indexes of bone metabolism and gender,age and season in adult residents.Methods The data of 6462 cases of physical examination in the physical examination center of the First Affiliated Hospital of Kunming Medical University from January 2021 to April 2024 were retrospectively analyzed.Gender,age,25-hydroxyvitamin D(25-OH-VD),calcitonin(CT),n-terminal osteocalcin(N-MID),andβ-collagen degradation products(Beta-CrossLaps,β-CTX)of all subjects were collected.The data were grouped according to the reference value range,gender,age and season of biochemical indicators of bone metabolism.SPSS29.0 software was used to conduct the overall level distribution statistics of the data,compare the differences in the level of biochemical indicators of bone metabolism between groups,analyze the correlation between the level of biochemical indicators of bone metabolism,and explore the influencing factors of biochemical indicators of bone metabolism.Results The overall median levels of biochemical indices were 25-OH-VD 61.93(49.17,77.12)nmol/L,CT1.43(.53,3.01)pg/mL,N-MID16.0(12.8,20.2)ng/mL,β-CTX397.0(295.0,527.0)pg/mL.N-MID was significantly positively correlated withβ-CTX(rs=0.748).The effects of gender,age and season on 25-OH-VD and N-MID were statistically significant(P<0.05).Conclusion The overall median 25-OH-VD levels in this study population are lower than the normal reference range,and vitamin D levels are generally insufficient and more common in the younger study population,suggesting that vitamin D supplementation may be an general public health issue.The overall median CT,N-MID andβ-CTX levels are in the normal reference range,indicating that the population is in good health on these indicators.Gender and age are significant factors affecting 25-OH-VD,CT and N-MID levels.Age is a significant factor affecting 25-OH-VD and N-MID levels.Season is a significant factor affecting the levels of 25-OH-VD,N-MID andβ-CTX.N-MID andβ-CTX may have a close biological relationship.