中药小分子治疗骨关节炎的研究进展

Research progress on the treatment of osteoarthritis with small molecules derived from traditional Chinese medicine:A review of literatures

骨性关节炎(osteoarthritis, OA)是临床常见的慢性退行性疾病,危害巨大但尚无特效治疗方法。近年来,越来越多从传统中药中提取的小分子被用于OA的实验研究甚至临床治疗。中药小分子既能在一定程度上遵循OA治疗相关的传统中医理论,又因其化学结构式清晰,且疗效的普适性和可重复性较强,作用机制相对明确,所以逐渐受到基础研究与临床实践领域的重视。为了推动本领域的发展,为研究者和临床医生提供相关的背景资料和线索,本文系统地综述了常用中药小分子(例如姜黄素、白术内酯、白藜芦醇等)在治疗OA的疗效及其内在机制方面的最新进展。

Osteoarthritis(OA)is a prevalent chronic degenerative disease in clinical practice,posing significant health threats while lacking specific effective treatments.In recent years,an increasing number of small molecules derived from traditional Chinese medicine have been utilized in experimental studies and clinical treatment of OA.The utilization of these small molecules aligns to a certain extent with traditional Chinese medical theories related to OA treatment.Moreover,due to their well‑defined chemical structures and the reproducibility of their effects,along with relatively well‑understood mechanisms,these compounds are gaining growing attention in the fields of OA research and clinical practice.To advance this field's development,this article systematically reviews the therapeutic efficacy and underlying mechanisms of various small molecules used for treating OA including curcumin,atractylenolide,resveratrol etc.,aiming to provide relevant background information and insights for researchers and clinicians.