绒毛膜羊膜炎与新生儿相关疾病的研究进展

Research progress on chorioamnionitis and related neonatal diseases

绒毛膜羊膜炎(chorioamnionitis, CAM)是指病原体感染胎盘的绒毛膜羊膜和蜕膜而形成的炎症。CAM会导致早产,使新生儿发生呼吸窘迫综合征、支气管肺发育不良等不良结局的风险增加,以及使新生儿围产期的死亡率上升。因此,早期识别、诊断及治疗CAM对于提高孕产妇及新生儿的救治成功率、改善新生儿的生存质量及疾病预后具有重要意义。该综述旨在阐述CAM与新生儿相关疾病的关系及防治的研究现状,为更好管理CAM相关新生儿提供临床治疗新思路。

Chorioamnionitis(CAM)refers to an inflammatory condition resulting from pathogen infection of the chorion,amnion,and decidua of the placenta.CAM is associated with preterm birth and an increased risk of adverse outcomes in neonates,including respiratory distress syndrome,bronchopulmonary dysplasia,and elevated perinatal mortality rates.Therefore,early identification,diagnosis,and treatment of CAM are crucial for optimizing therapeutic success in pregnant women and newborns while enhancing the quality of life and disease prognosis for neonates.This review aims to elucidate the correlation between CAM and neonatal diseases as well as provide insights into current prevention strategies and treatment approaches to offer novel clinical perspectives for improved management of CAM⁃related newborns.