中医利水渗湿法治疗痛风性肾纤维化最新研究进展

Latest Research Progress of Clearing Damp and Promoting Diuresis of Traditional Chinese Medicine for Gouty Renal Fibrosis

纤维化是痛风性肾病进展至终末期肾衰竭的共同通路,中医基于“脾肾亏虚、水湿内停、痰浊结聚、瘀血凝滞”基本病机,以“利水渗湿”为法在治疗和调控痛风性肾纤维化临床疗效显著。本研究以痛风性肾纤维化、痛风性肾病、中医、中药等为关键词,通过中国知网(CNKI)、万方数据库(WF)、重庆维普数据库(VIP)三大中文数据库及PubMed数据库检索近20年相关文献,系统综述痛风性肾纤维化的中医病理机制和具有“利水渗湿”功效中药及复方抗痛风性肾纤维化最新研究进展,旨在为中医“利水渗湿”法治疗痛风性肾纤维化研究提供参考和思路。

Fibrosis is a common pathway for gouty nephropathy to progression to end-stage renal failure.Based on the TCM theory of spleen and kidney deficiency,water-damp internal retention,phlegm-turbidity accumulation and blood stasis coagulation stagnation,it has been shown to have remarkable clinical effect in the treatment and regulation of gouty renal fibrosis by clearing damp and promoting diuresis.The research concerned on relevant literatures in the past 20 years,which were retrieved in the three Chinese databases of CNKI,WF,VIP and PubMed database,and searched by keywords such as gouty renal fibrosis,gouty nephropathy,traditional Chinese medicine,etc.This article systematically reviews the TCM pathological mechanisms of gouty renal fibrosis and the latest research progress of clearing damp and promoting diuresis of TCM and compound anti-gouty renal fibrosis,aiming to provide reference and ideas for the treatment of gouty renal fibrosis with TCM clearing damp and promoting diuresis.