促进创面愈合水凝胶材料研究现状及发展趋势的文献计量及可视化分析

Research status and development trend of hydrogel materials promoting wound healing:bibliometric and visual analysis

目的对促进创面愈合的水凝胶材料相关文献进行可视化分析,探讨该领域的研究现状、热点及未来的发展趋势,为之后的研究发展提供参考。方法检索Web of Science数据库核心合集收录的水凝胶材料促进创面愈合的相关文献,时间限定为2010年1月1日至2023年10月1日。采用文献计量学方法对纳入文献的年份、作者、出版刊物、国家和机构发文量、累计被引频次、共被引频次以及关键词等信息进行整合;应用VOSviewer 1.6.19及CiteSpace 6.2.R4软件进行文献可视化分析并绘制图谱。结果共纳入3863篇文献,涉及18921名作者,2010至2023年间该领域的发文量呈现明显上升的趋势。发文量最多的研究者赵远锦(Zhao YJ),共发文38篇。有557种期刊收录过相关文献,发文量最多的是International Journal of Biological Macromolecules,共发文286篇。纳入文献源自92个国家、3307个机构,其中中国发表的文献量最多,研究机构主要来自中国和美国。累计被引频次最高的文献为"Alginate:properties and biomedical applications",总被引频次达4737次。累计共被引频次最高的是2018年Qu J等发表的文献,共被引频次达404次。关键词共现、聚类、时间线及突现分析显示,该领域前期研究主要聚焦于创面愈合的过程及分子水平的细胞机制,后期逐渐关注开发水凝胶支架中纳米颗粒和抗菌化合物的精确控释功能。结论水凝胶材料在创面愈合中应用的研究正在受到越来越多的国际关注。依据热点词的变化,该领域未来的研究趋势是开发具有创面监测、控制给药、功能多样化的智能调节型水凝胶。

Objective To conduct a visual analysis of the related literature on hydrogel materials that promote wound healing,and to explore the research status,hotspots and future development trends in this field,in order to provide a reference for future research and development.Methods The Web of Science Core Collection database was searched to obtain relevant literature on the promotion of wound healing by hydrogel materials from January 1,2010 to October 1,2023.Bibliometrics method were used to integrate the year,author,publication,number of national and institutional publications,cumulative citation and co-citation frequency and key words of the included literatures.VOSviewer 1.6.19 and CiteSpace 6.2.R4 were used for the literature’s visualization analysis and mapping.Results A total of 3863 literatures were included,involving 18921 authors,and the number of publications in this field showed a significant increasing trend from 2010 to 2023.Zhao YJ,the researcher with the most publications,published 38 articles.There were 557 journals that had collected relevant literatures,and the International Journal of Biological Macromolecules had published the most literature,with a total of 286 publications.A total of 92 countries and 3307 institutions had conducted research in related fields,with China publishing the most papers.Research institutions mainly come from China and the United States.The literature with the highest cumulative citation frequency was"Alginate:properties and biomedical applications",which reached 4737 times.The highest cumulative co-citation frequency was the literature published by Qu J,et al in 2018,with a total of 404 times.Keyword co-occurrence,clustering,time line and emergence analysis showed that the early research in this field mainly focused on the process of wound healing and the cellular mechanism at the molecular level,and later gradually focused on the development of precise controlled release function of nanoparticles and antibacterial compounds in hydrogel scaffolds.Conclusion Research on the application of hydrogel materials in wound healing is attracting increasing international attention.According to the changes of hot words,the future research trend in this field is to develop intelligent hydrogels with regulatory capabilities,wound monitoring,controlled drug delivery and diversified functions.