姜黄素对LPS诱导体外巨噬细胞分泌TNF-α影响的meta分析

A Meta-analysis of the Effect of Curcumin on TNF-αExpression in Macrophages Induced by LPS

目的:探讨姜黄素对脂多糖(LPS)诱导巨噬细胞产生细胞因子TNF-α的影响。方法:检索国内外全文数据库有关姜黄素与细胞因子TNF-α浓度关系的文献,检索起止时间均从建库至2023年11月,采用RevMan 5.3分析软件对文献资料进行定量综合。结果:根据文献纳入和排除标准,共纳入8篇相关文献;荟萃分析表明,姜黄素+LPS组与LPS组相比,巨噬细胞产生的TNF-α浓度差异有统计学意义(P<0.05),合并后总体MD值为-506.336,95%CI为(-770.06~-242.66);各研究之间存在较强的异质性,亚组分析发现巨噬细胞种类是异质性重要来源。结论:姜黄素能够抑制激活的巨噬细胞产生炎症因子TNF-α,这可能是姜黄素的抗炎机制之一。

Objective:To investigate the effect of curcumin on TNF-α secreted by macrophages induced by lipopolysaccharide(LPS).Methods:Literature on the relationship between curcumin and cytokine TNF-α concentration in full-text databases were searched and the search starts from the database construction to November 2023.Quantitative synthesis of the literature data was performed using RevMan5.3 analysis software.Results:According to the inclusion and exclusion criteria of the literature,a total of 8 related articles were included.The meta-analysis results showed that the difference in TNF-α concentrations produced by macrophages in the curcumin+LPS group compared with the LPS group was significant(P<0.05).The combined overall MD value was-506.336,with a 95%CI of(-770.06 to-242.66).There was strong heterogeneity among the studies,and the subgroup analysis revealed that macrophage species were an important source of heterogeneity.Conclusion:Curcumin is able to inhibit the production of the inflammatory factor TNF-α by activated macrophages,which may be one of the anti-inflammatory mechanisms of curcumin.