磁共振成像联合血清糖类抗原125、血管生成素样蛋白2检测对乳腺癌的诊断效能

Diagnostic efficacy of magnetic resonance imaging combined with serum carbohydrate antigen 125 and angiopoietin like protein 2 in breast cancer

目的探讨磁共振成像(magnetic resonance imaging,MRI)联合血清糖类抗原(CA)125、血管生成素样蛋白(ANGPTL)2对乳腺癌的诊断效能。方法2020年2月~2022年6月收治的初步诊断为乳腺病变病人152例,根据病理组织检查(乳腺癌改良根治术或穿刺活检)结果分为乳腺癌组(90例)和良性组(62例),所有病人均进行MRI检查,检测病人血清CA125和ANGPTL2水平;绘制ROC曲线分析MRI联合血清CA125、ANGPTL2对乳腺癌的临界诊断点;采用四格表分析MRI联合血清CA125、ANGPTL2对乳腺癌的诊断价值。结果乳腺癌组环形强化病人比例高于良性组,良性组均匀强化病人比例高于乳腺癌组,乳腺癌组血清CA125、ANGPTL2水平高于良性组,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,血清CA125诊断乳腺癌的AUC为0.870(95%CI:0.815~0.924),截断值为29.574 U/ml,血清ANGPTL2诊断乳腺癌的AUC为0.893(95%CI:0.843~0.942),截断值为6.085 ng/ml,MRI诊断乳腺癌的AUC为0.891(95%CI:0.832~0.950)。MRI、CA125、ANGPTL2及三者联合在乳腺癌诊断中准确度分别为89.47%、84.87%、82.89%、93.42%。结论MRI联合血清CA125、ANGPTL2可以提高乳腺癌的诊断效能。

Objective To explore the diagnostic efficacy of magnetic resonance imaging(MRI)combined with serum carbohydrate antigen 125(CA125)and angiopoietin like protein 2(ANGPTL2)in breast cancer.Methods From February 2020 to June 2022,152 patients with breast diseases diagnosed initially in our hospital were collected as the subjects of this study.According to the results of pathological tissue examination(breast cancer modified radical mastectomy operation or needle biopsy),they were grouped into breast cancer group(90 cases)and benign group(62 cases).All patients underwent MRI examination.Measurement of serum CA125 and ANGPTL2 levels;receiver Operating Characteristic curve(ROC)were analysed for the critical diagnostic points of breast cancer by MRI combined with serum CA125 and ANGPTL2;and four grid table was applied to analyze the diagnostic value of MRI combined with serum CA125 and ANGPTL2 in breast cancer.Results The ring enhancement in breast cancer group was obviously higher than that in benign group(P<0.05),and the uniform enhancement in benign group was obviously higher than that in breast cancer group(P<0.05).The levels of serum CA125 and ANGPTL2 in breast cancer group were obviously higher than those in benign group(P<0.05).According to the ROC,the AUC of serum CA125 in the diagnosis of breast cancer was 0.870(95%CI:0.815~0.924)and the cut-off value was 29.574 U/ml,the AUC of serum ANGPTL2 CA125 in the diagnosis of breast cancer was 0.893(95%CI:0.843~0.942),the cut-off value was 6.085 ng/ml,and the AUC of MRI diagnosis of breast cancer was 0.891(95%CI:0.832~0.950).The accuracy of MRI,CA125,ANGPTL2 and combination of three indexes in the diagnosis of breast cancer were 89.47%,84.87%,82.89%,93.42%respectively.Conclusion MRI combined with serum CA125 and ANGPTL2 can improve the diagnostic efficacy of breast cancer.